[HTML][HTML] Advancing pain understanding and drug discovery: insights from preclinical models and recent research findings

YI Asiri, SS Moni, M Ramar, K Chidambaram - Pharmaceuticals, 2024 - mdpi.com
Despite major advancements in our understanding of its fundamental causes, pain—both
acute and chronic—remains a serious health concern. Various preclinical investigations …

Molecular targets in bone cancer pain: a systematic review of inflammatory cytokines

J Ruivo, I Tavares, DH Pozza - Journal of Molecular Medicine, 2024 - Springer
Bone cancer pain (BCP) profoundly impacts patient's quality of life, demanding more
effective pain management strategies. The aim of this systematic review was to investigate …

Tumor necrosis factor alpha secreted from oral squamous cell carcinoma contributes to cancer pain and associated inflammation

NN Scheff, Y Ye, A Bhattacharya, J MacRae… - Pain, 2017 - journals.lww.com
Patients with oral cancer report severe pain during function. Inflammation plays a role in the
oral cancer microenvironment; however, the role of immune cells and associated secretion …

Transient receptor potential ankyrin 1 (TRPA1) plays a critical role in a mouse model of cancer pain

CTDD Antoniazzi, R Nassini, FK Rigo… - … journal of cancer, 2019 - Wiley Online Library
There is a major, unmet need for the treatment of cancer pain, and new targets and
medicines are required. The transient receptor potential ankyrin 1 (TRPA1), a cation channel …

[HTML][HTML] The endocannabinoid system: Novel targets for treating cancer induced bone pain

J Sun, YQ Zhou, SP Chen, X Wang, BY Xu… - Biomedicine & …, 2019 - Elsevier
Treating Cancer-induced bone pain (CIBP) continues to be a major clinical challenge and
underlying mechanisms of CIBP remain unclear. Recently, emerging body of evidence …

影响慢性中重度癌痛患者疼痛治疗效果的相关因素分析

王楠娅, 刘玉梅, 赵恒军, 何华, 李薇 - 中国肿瘤临床, 2020 - cjco.cn
影响慢性中重度癌痛患者疼痛治疗效果的相关因素分析 首页 期刊简介 1.期刊介绍 2.获奖情况
编委会 期刊在线 1.最新录用 2.优先发表 3.当期目录 4.过刊浏览 视频合辑 在线投稿 1.投稿须知 …

Characterization of cancer-induced nociception in a murine model of breast carcinoma

AS de Almeida, FK Rigo, SDT De Prá, AM Milioli… - Cellular and Molecular …, 2019 - Springer
Severe and poorly treated pain often accompanies breast cancer. Thus, novel mechanisms
involved in breast cancer-induced pain should be investigated. Then, it is necessary to …

Optimization and In Vivo Profiling of a Refined Rat Model of Walker 256 Breast Cancer Cell-Induced Bone Pain Using Behavioral, Radiological, Histological …

P Shenoy, A Kuo, I Vetter, MT Smith - Frontiers in pharmacology, 2017 - frontiersin.org
In the majority of patients with advanced breast cancer, there is metastatic spread to bones
resulting in pain. Clinically available drug treatments for alleviation of breast cancer-induced …

Yokukansan Alleviates Cancer Pain by Suppressing Matrix Metalloproteinase‐9 in a Mouse Bone Metastasis Model

K Nakao, A Fujiwara, N Komasawa… - Evidence‐Based …, 2019 - Wiley Online Library
Bone cancer pain control is difficult because it includes various characteristics of pain such
as nociceptic and neuropathic pain. In this study, we investigated the effect of yokukansan …

Users' perceptions on digital visualization of neuropathic cancer-related pain

EAA Jaatun, M Fallon… - Health Informatics …, 2019 - journals.sagepub.com
Quality pain management implies a thorough pain assessment with structured
communication between patients and healthcare providers. Pain distribution is an important …