Biological functions and applications of LncRNAs in the regulation of the extracellular matrix in osteoarthritis

D Shi, Y Mei, W Hao, J Li, S Liu, X Lin - Frontiers in Cell and …, 2024 - frontiersin.org
Osteoarthritis (OA) is a major cause of disability, characterized by chronic pain, irreversible
destruction, and loss of function of the articular cartilage. The integrity and arrangement of …

Emerging role of lncRNAs in osteoarthritis: An updated review

R Wang, HT Shiu, WYW Lee - Frontiers in immunology, 2022 - frontiersin.org
Osteoarthritis (OA) is a prevalent joint disease, which is associated with progressive articular
cartilage loss, synovial inflammation, subchondral sclerosis and meniscus injury. The …

Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritis

R Coutinho de Almeida, M Tuerlings, Y Ramos… - …, 2023 - academic.oup.com
Objectives To present an unbiased approach to identify positional transcript single
nucleotide polymorphisms (SNPs) of osteoarthritis (OA) risk loci by allelic expression …

Long non-coding RNA PVT1 and its target miRNA-146a as potential prognostic biomarkers in rheumatoid arthritis patients

R Erfan, OG Shaker, MAF Khalil, YA Elsabagh… - Life, 2021 - mdpi.com
Objective: Long non-coding RNAs (lncRNAs) and their target microRNAs were documented
in multiple studies to have a significant role in different joint disorders such as rheumatoid …

A Damaging COL6A3 Variant Alters the MIR31HG‐Regulated Response of Chondrocytes in Neocartilage Organoids to Hyperphysiologic Mechanical Loading

NGC Bloks, Z Harissa, G Mazzini, SS Adkar… - Advanced …, 2024 - Wiley Online Library
The pericellular matrix (PCM), with its hallmark proteins collagen type VI (COLVI) and
fibronectin (FN), surrounds chondrocytes and is critical in transducing the biomechanical …

Comprehensive analysis on subchondral bone marrow lesions of human osteoarthritis by integrating bulk and single-cell transcriptomes

M Zeng, X Wang, T Chen, G Ruan, J Li, S Xue… - BMC Musculoskeletal …, 2023 - Springer
Objective This study aims to demonstrate the cellular composition and underlying
mechanisms in subchondral bone marrow lesions (BMLs) of knee osteoarthritis (OA) …

[HTML][HTML] RNA-seq identifies differentially expressed genes involved in csal1 overexpression in granulosa cells of prehierarchical follicles in Chinese Dagu hens

H Zhu, Y Ding, J Zhu, L Zhao, Y Su, S Zhao - Poultry Science, 2023 - Elsevier
The transcription factor csal1 is an important molecule that plays a critical regulatory function
in ovarian follicle development, as confirmed by our previous data. However, the candidate …

Coding and noncoding RNA profile of human heterotopic ossifications-Risk factors and biomarkers

B Mierzejewski, Ł Pulik, I Grabowska, A Sibilska… - Bone, 2023 - Elsevier
Heterotopic ossification (HO) means the formation of bone in muscles and soft tissues, such
as ligaments or tendons. HO could have a genetic history or develop after a traumatic event …

Unraveling the Molecular Landscape of Osteoarthritis: A Comprehensive Review Focused on the Role of Non-Coding RNAs

M Shakeri, A Aminian, K Mokhtari, M Bahaeddini… - … -Research and Practice, 2024 - Elsevier
Osteoarthritis (OA) poses a significant global health challenge, with its prevalence
anticipated to increase in the coming years. This review delves into the emerging molecular …

LncRNA AC005165. 1 Alleviates IL-1β-Induced Osteoarthritis via miR-199a-3p/TXNIP Axis

X Gu, T Xie - Biochemical Genetics, 2024 - Springer
Osteoarthritis (OA) is a chronic musculoskeletal disease and often causes impaired joint
mobility and disability. Long noncoding RNAs (lncRNAs) play pivotal roles in OA …