Ageing of human skin may result from both the passage of time (intrinsic ageing) and from
cumulative exposure to external influences (extrinsic ageing) such as ultraviolet radiation …

Cardiovascular diseases (CVDs) are the leading cause of death worldwide and represent a
major problem of public health. Over the years, life expectancy has considerably increased …

Abdominal aortic aneurysms (AAAs) are characterized by chronic inflammatory cell
infiltration. AAA is typically an asymptomatic disease and caused≈ 15 000 deaths annually …

Thoracic aortic aneurysms (TAA) increase the risk of aortic dissection or rupture and
represent an important source of morbidity and mortality. Inherited forms of the disease …

Classically, the extracellular matrix (ECM) was viewed as a supporting structure for
stabilizing the location of cells in tissues and for preserving the architecture of tissues. This …

Thoracic aortic dissection (TAD) is a highly lethal vascular disease. In many patients with
TAD, the aorta progressively dilates and ultimately ruptures. Dissection formation …

Recent pregnancy correlates with decreased survival for breast cancer patients compared
with non–pregnancy-associated breast cancer. We hypothesize that postpartum mammary …

OBJECTIVE Dysbiosis of the gut microbiota has been linked to disease pathogenesis in type
1 diabetes, yet the functional consequences to the host of this dysbiosis are unknown. We …

Thoracic aortic aneurysm (TAA) is the life-threatening complication of Marfan syndrome
(MFS), a connective tissue disorder caused by mutations in the fibrillin-1 gene. TAA is …

The extracellular matrix plays a key role in organ formation and tissue homeostasis. Recent
studies have revealed that fibrillin assemblies (microfibrils) confer both tissue integrity and …