The nonobese diabetic (NOD) mouse is a model of human autoimmune insulin-dependent
diabetes mellitus. The NOD mouse also serves as a model for studying complex polygenic …

Susceptibility to complex autoimmune diseases (AIDs) is a multigenic phenotype affected by
a variety of genetic and environmental or stochastic factors. After over a decade of linkage …

Abstract Type 1 diabetes (T1D) is characterized by the destruction of pancreatic β-cells.
Several observations have renewed the interest in β-cell RNA sensors and editors. Here, we …

The common occurrence of hearing loss in both humans and mice, and the anatomical and
functional similarities of their inner ears, attest to the potential of mice being used as models …

Graft failure in the transplantation of hematopoietic stem cells occurs despite donor-host
genetic identity of human leukocyte antigens, suggesting that additional factors modulate …

Human clinical trials in type 1 diabetes (T1D) patients using mesenchymal stem cells (MSC)
are presently underway without prior validation in a mouse model for the disease. In …

Mice homozygous for the fat mutation develop obesity and hyperglycaemia that can be
suppressed by treatment with exogenous insulin. The fat mutation maps to mouse …

Precise definition of the role of both CD4 and CD8 T-cell subsets from NOD mice in the
adoptive transfer of diabetes has been complicated by the possibility that endogenous T …

KNOWING the autoantigen target (s) in an organ-specific autoimmune disease is essential
to understanding its pathogenesis. Insulin-dependent diabetes mellitus (IDDM) is an …

Aims/hypothesis Improved biomarkers are acutely needed for the detection of developing
type 1 diabetes, prior to critical loss of beta cell mass. We previously demonstrated that …