Uncovering post-translational modification-associated protein–protein interactions
In living systems, the chemical space and functional repertoire of proteins are dramatically
expanded through the post-translational modification (PTM) of various amino acid residues …
expanded through the post-translational modification (PTM) of various amino acid residues …
Genetically encoded crosslinkers to address protein–protein interactions
Noncanonical amino acids (ncAAs) for photo‐and chemical crosslinking are powerful
biochemical tools for studying and manipulating interactions between proteins both in vitro …
biochemical tools for studying and manipulating interactions between proteins both in vitro …
Photo-cross-linking to delineate epigenetic interactome
Covalent modifications of DNA and histones are key cellular epigenetic marks to regulate
gene functions. Most of these epigenetic marks are added or removed by corresponding …
gene functions. Most of these epigenetic marks are added or removed by corresponding …
Construction and Catalytic Study of Affinity Peptide Orientation and Light Crosslinking Immobilized Sucrose Isomerase
N Shi, M Zheng, X Wu, N Chen, L Jiang… - Journal of Agricultural …, 2023 - ACS Publications
A novel affinity peptide orientation and light-controlled covalent immobilized method was
developed. Sucrose isomerase (SI) was selected as the model enzyme. Molecular …
developed. Sucrose isomerase (SI) was selected as the model enzyme. Molecular …
Molecular insights into the recognition of acetylated histone modifications by the BRPF2 bromodomain
HBO1 [HAT bound to the origin recognition complex (ORC)], a member of the MYST family of
histone acetyltransferases (HATs), was initially identified as a binding partner of ORC that …
histone acetyltransferases (HATs), was initially identified as a binding partner of ORC that …
Uncovering the non-histone interactome of the BRPF1 bromodomain using site-specific azide-acetyllysine photochemistry
Bromodomain-PHD finger protein 1 (BRPF1) belongs to the BRPF family of bromodomain-
containing proteins. Bromodomains are exclusive reader modules that recognize and bind …
containing proteins. Bromodomains are exclusive reader modules that recognize and bind …
Uncovering the domain-specific interactome of the TAF1 tandem reader using site-specific azide-acetyllysine photochemistry
Combinatorial readout of histone post-translational modifications by tandem reader modules
mediates crosstalk among different histone modifications. To identify the domain-specific …
mediates crosstalk among different histone modifications. To identify the domain-specific …
Novel insights into the recognition of acetylated histone H4 tail by the TRIM24 PHD-Bromo module
TRIM24 is a multi-functional chromatin reader, and it binds to the estrogen receptor to
activate estrogen-dependent target genes associated with tumor development. TRIM24 is …
activate estrogen-dependent target genes associated with tumor development. TRIM24 is …
基因编码非天然氨基酸技术及其在生物医学领域的应用
朱银雪， 王德祥， 孔影， 陆文捷， 叶慧， 郝海平 - 中国药科大学学报, 2022 - jcpu.cpu.edu.cn
人体内蛋白质通常由20 种天然氨基酸组成. 氨基酸的不同排列组合及立体构象是构建丰富多样
性的蛋白质的基础. 近年来开发的突破性基因密码子拓展技术通过向目标蛋白质中定向引入非 …
性的蛋白质的基础. 近年来开发的突破性基因密码子拓展技术通过向目标蛋白质中定向引入非 …
Genetic incorporation of unnatural amino acids into proteins and its translational application in biomedicine
ZHU Yinxue, W Dexiang, K Ying… - Journal of China …, 2022 - jcpu.cpu.edu.cn
Proteins in the human body are usually made of 20 natural amino acids. Through different
amino acid combinations and isomerization, proteins of diverse functions are built. An …
amino acid combinations and isomerization, proteins of diverse functions are built. An …