Genes and molecular pathways underpinning ciliopathies
Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The
dysfunction of cilia causes diseases known as ciliopathies. The number of reported …
dysfunction of cilia causes diseases known as ciliopathies. The number of reported …
Signaling through the primary cilium
G Wheway, L Nazlamova, JT Hancock - Frontiers in cell and …, 2018 - frontiersin.org
The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been
well described since the 1960s. However, for decades these organelles were believed to be …
well described since the 1960s. However, for decades these organelles were believed to be …
[HTML][HTML] Dual proteome-scale networks reveal cell-specific remodeling of the human interactome
Thousands of interactions assemble proteins into modules that impart spatial and functional
organization to the cellular proteome. Through affinity-purification mass spectrometry, we …
organization to the cellular proteome. Through affinity-purification mass spectrometry, we …
The molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains
Anterograde intraflagellar transport (IFT) trains are essential for cilia assembly and
maintenance. These trains are formed of 22 IFT-A and IFT-B proteins that link structural and …
maintenance. These trains are formed of 22 IFT-A and IFT-B proteins that link structural and …
Motile and non‐motile cilia in human pathology: from function to phenotypes
HM Mitchison, EM Valente - The Journal of pathology, 2017 - Wiley Online Library
Ciliopathies are inherited human disorders caused by both motile and non‐motile cilia
dysfunction that form an important and rapidly expanding disease category. Ciliopathies are …
dysfunction that form an important and rapidly expanding disease category. Ciliopathies are …
The intraflagellar transport machinery
M Taschner, E Lorentzen - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Eukaryotic cilia and flagella are evolutionarily conserved organelles that protrude from the
cell surface. The unique location and properties of cilia allow them to function in vital …
cell surface. The unique location and properties of cilia allow them to function in vital …
Biochemically validated structural model of the 15‐subunit intraflagellar transport complex IFT‐B
NA Petriman, M Loureiro‐López, M Taschner… - The EMBO …, 2022 - embopress.org
Cilia are ubiquitous eukaryotic organelles impotant for cellular motility, signaling, and
sensory reception. Cilium formation requires intraflagellar transport of structural and …
sensory reception. Cilium formation requires intraflagellar transport of structural and …
PaxDb 5.0: curated protein quantification data suggests adaptive proteome changes in yeasts
Abstract The" Protein Abundances Across Organisms" database (PaxDb) is an integrative
metaresource dedicated to protein abundance levels, in tissue-specific or whole-organism …
metaresource dedicated to protein abundance levels, in tissue-specific or whole-organism …
hu. MAP 2.0: integration of over 15,000 proteomic experiments builds a global compendium of human multiprotein assemblies
A general principle of biology is the self‐assembly of proteins into functional complexes.
Characterizing their composition is, therefore, required for our understanding of cellular …
Characterizing their composition is, therefore, required for our understanding of cellular …
Integration of over 9,000 mass spectrometry experiments builds a global map of human protein complexes
Macromolecular protein complexes carry out many of the essential functions of cells, and
many genetic diseases arise from disrupting the functions of such complexes. Currently …
many genetic diseases arise from disrupting the functions of such complexes. Currently …