Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS,
which can be compared across CNS regions, patients, and centres. In patients with multiple …

Pathological evaluation is the gold standard for identifying processes related to multiple
sclerosis that explain disease manifestations, and for guiding the development of new …

Multiple sclerosis is a complex and heterogeneous, most likely autoimmune, demyelinating
disease of the central nervous system (CNS). Although a number of histological …

Chronic active and slowly expanding lesions with smouldering inflammation are
neuropathological correlates of progressive multiple sclerosis pathology. T1 hypointense …

Objective The aim of this work was to determine whether atrophy of specific retinal layers
and brain substructures are associated over time, in order to further validate the utility of …

The differential diagnosis of parkinsonian syndromes is considered one of the most
challenging in neurology and error rates in the clinical diagnosis can be high even at …

BACKGROUND. In some active multiple sclerosis (MS) lesions, a strong immune reaction at
the lesion edge may contain growth and thereby isolate the lesion from the surrounding …

Background: Chronic lesion activity driven by smoldering inflammation is a pathological
hallmark of progressive forms of multiple sclerosis (MS). Objective: To develop a method for …

Hypomyelinating leukodystrophies constitute a subset of genetic white matter disorders
characterized by a primary lack of myelin deposition. Most patients with severe …

Substantial advances have elucidated some of the central mechanisms underlying the
inflammation, demyelination, and neurodegeneration that occur in multiple sclerosis …