Cerebral small vessel disease and Alzheimer's disease: a review
HW Kim, J Hong, JC Jeon - Frontiers in Neurology, 2020 - frontiersin.org
Alzheimer's disease (AD) is the most common cause of dementia. Despite this, clear
pathophysiology for AD has not been confirmed, and effective treatments are still not …
pathophysiology for AD has not been confirmed, and effective treatments are still not …
MRI-based biomarkers of accelerated aging and dementia risk in midlife: how close are we?
ML Elliott - Ageing research reviews, 2020 - Elsevier
The global population is aging, leading to an increasing burden of age-related
neurodegenerative disease. Efforts to intervene against age-related dementias in older …
neurodegenerative disease. Efforts to intervene against age-related dementias in older …
Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function
K Koizumi, Y Hattori, SJ Ahn, I Buendia… - Nature …, 2018 - nature.com
The ApoE4 allele is associated with increased risk of small vessel disease, which is a cause
of vascular cognitive impairment. Here, we report that mice with targeted replacement (TR) …
of vascular cognitive impairment. Here, we report that mice with targeted replacement (TR) …
Vascular ApoE4 impairs behavior by modulating gliovascular function
The ε4 allele of the apolipoprotein E gene (APOE4) is a strong genetic risk factor for
Alzheimer's disease (AD) and multiple vascular conditions. ApoE is abundantly expressed in …
Alzheimer's disease (AD) and multiple vascular conditions. ApoE is abundantly expressed in …
The association between white matter hyperintensities and amyloid and tau deposition
White matter hyperintensities (WMHs) frequently occur in Alzheimer's Disease (AD) and
have a contribution from ischemia, though their relationship with β-amyloid and …
have a contribution from ischemia, though their relationship with β-amyloid and …
Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals
White matter hyperintensities (WMH) are commonly detected in the brain of elderly
individuals and have been associated with a negative impact on multiple cognitive domains …
individuals and have been associated with a negative impact on multiple cognitive domains …
APOE-ε4 genotype and dementia before and after transient ischemic attack and stroke: population-based cohort study
ST Pendlebury, D Poole, A Burgess, J Duerden… - Stroke, 2020 - Am Heart Assoc
Background and Purpose—APOE-ε4 genotype is a risk factor for sporadic Alzheimer
disease and reduced recovery from brain injury. Since data on APOE genotype and …
disease and reduced recovery from brain injury. Since data on APOE genotype and …
A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury
A Anfray, S Schaeffer, Y Hattori, MM Santisteban… - Nature …, 2024 - nature.com
Abstract Apolipoprotein E4 (ApoE4), the strongest genetic risk factor for sporadic Alzheimer's
disease, is also a risk factor for microvascular pathologies leading to cognitive impairment …
disease, is also a risk factor for microvascular pathologies leading to cognitive impairment …
Spatial patterns of white matter hyperintensities associated with Alzheimer's disease risk factors in a cognitively healthy middle-aged cohort
Background White matter hyperintensities (WMH) of presumed vascular origin have been
associated with an increased risk of Alzheimer's disease (AD). This study aims to describe …
associated with an increased risk of Alzheimer's disease (AD). This study aims to describe …
[HTML][HTML] LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4
Cerebrovasculature is critical in maintaining brain homeostasis; its dysregulation often leads
to vascular cognitive impairment and dementia (VCID) during aging. VCID is the second …
to vascular cognitive impairment and dementia (VCID) during aging. VCID is the second …