In textbook illustrations of migrating cells, actomyosin contractility is typically depicted as the
contraction force necessary for cell body retraction. This dogma has been transformed by the …

Migration of endothelial and many other cells requires spatiotemporal regulation of
protrusive and contractile cytoskeletal rearrangements that drive local cell shape changes …

Blebs, spherical membrane bulges of the cell membrane, are ubiquitous structures observed
in various biological phenomena, including apoptosis, cell division, to bleb-based cell …

Molecular simulation approaches to probing the effects of mechanical forces in the actin
cytoskeleton - PMC Skip to main content Here's how you know Official websites use .gov A .gov …

The actomyosin cytoskeleton generates mechanical forces that power important cellular
processes, such as cell migration, cell division, and mechanosensing. Actomyosin self …

The ability of cells to sense the mechanical properties of their microenvironment is essential
to many physiological processes. Previously, the molecular clutch theory was developed to …

Myosin 2 dynamically assembles into filaments that exert force on the actin cytoskeleton. To
form filaments, myosin 2 monomers transition between folded and unfolded states. Monomer …

We report that the RhoA-specific guanine nucleotide exchange factor ARHGEF17 localizes
at the back of a fibroblast's contractile lamella and regulates its disassembly. This …