Brain macrophages and microglia are centrally involved in immune surveillance of the
central nervous system. Upon inflammatory stimuli, they become reactive and release key …

Microglia are brain resident macrophages, which actively survey the surrounding
microenvironment and promote tissue homeostasis under physiological conditions. During …

Aging is intrinsically related to metabolic changes and characterized by the accumulation of
oxidative and inflammatory damage, as well as alterations in gene expression and activity of …

In experimental models, hypothalamic dysfunction is a key component of the
pathophysiology of diet-induced obesity. Early after the introduction of a high-fat diet …

Obesity remains a global health problem. Chronic low-grade inflammation in this pathology
has been related to comorbidities such as cognitive alterations that, in the long term, can …

Dietary restriction (DR) is defined as a moderate reduction in food intake while avoiding
malnutrition. The beneficial effects of DR are being increasingly acknowledged in aging and …

To determine whether voluntary exercise is capable of improving liver and adipose tissue
dysfunction caused by the high‐fat diet (HFD) combined with dietary advanced glycation …

Diet-induced obesity can originate from the dysregulated activity of hypothalamic neuronal
circuits, which are critical for the regulation of body weight and food intake. The exact …

It has been proven that mRNA vaccines are highly effective against the COVID-19 outbreak,
and low prevalence of side effects has been shown. However, there are still many gaps in …

The hypothalamus, as a vital brain region for endocrine and metabolism regulation,
undergoes functional disruption during obesity. The anti-aging effect of metformin has come …