The histone deacetylase (HDAC) enzymes, a class of epigenetic regulators, are historically
well established as attractive therapeutic targets. During investigation of trends within …

Angiotensin Converting Enzyme2 is the cell surface binding site for the coronavirus SARS‐
CoV‐2, which causes COVID‐19. We propose that an imbalance in the action of ACE1‐and …

The coronavirus disease 2019 (COVID‐19) pandemic caused by SARS‐CoV‐2 infections
has led to a substantial unmet need for treatments, many of which will require testing in …

Background and Purpose Cancer cells exhibit more dependence on iron and enhanced
sensitivity to iron‐dependent, programmed cell death (ferroptosis) than normal cells …

Mammalian models including non‐human primates, pigs and rodents have been used
extensively to study the mechanisms of cardiovascular disease. However, there is an …

Eight G protein‐coupled P2Y receptor subtypes respond to extracellular adenine and uracil
mononucleotides and dinucleotides. P2Y receptors belong to the δ group of rhodopsin‐like …

The COVID‐19 pandemic caused by the severe acute respiratory syndrome coronavirus 2
(SARS‐CoV‐2) has overwhelmed healthcare systems requiring the rapid development of …

Many countries have been affected by the worldwide outbreak of COVID‐19. Among
Western countries, Italy has been particularly hit at the beginning of the pandemic …

Therapeutic options for pulmonary arterial hypertension (PAH) have increased over the last
decades. The advent of pharmacological therapies targeting the prostacyclin, endothelin …

Background and Purpose Acute kidney injury is a common clinical problem with no definitive
or specific treatment. Therefore, the molecular mechanisms of acute kidney injury must be …