Advances in the development of influenza virus vaccines

F Krammer, P Palese - Nature reviews Drug discovery, 2015 - nature.com
Influenza virus infections are a major public health concern and cause significant morbidity
and mortality worldwide. Current influenza virus vaccines are an effective countermeasure …

Does influenza vaccination attenuate the severity of breakthrough infections? A narrative review and recommendations for further research

JM Ferdinands, MG Thompson, L Blanton, S Spencer… - Vaccine, 2021 - Elsevier
The effect of influenza vaccination on influenza severity remains uncertain. We reviewed the
literature for evidence to inform the question of whether influenza illness is less severe …

Prevention and attenuation of Covid-19 with the BNT162b2 and mRNA-1273 vaccines

MG Thompson, JL Burgess, AL Naleway… - … England Journal of …, 2021 - Mass Medical Soc
Background Information is limited regarding the effectiveness of the two-dose messenger
RNA (mRNA) vaccines BNT162b2 (Pfizer–BioNTech) and mRNA-1273 (Moderna) in …

Safety and efficacy of single-dose Ad26. COV2. S vaccine against Covid-19

J Sadoff, G Gray, A Vandebosch… - … England Journal of …, 2021 - Mass Medical Soc
Abstract Background The Ad26. COV2. S vaccine is a recombinant, replication-incompetent
human adenovirus type 26 vector encoding full-length severe acute respiratory syndrome …

[PDF][PDF] Global influenza strategy 2019-2030

World Health Organization - 2019 - apps.who.int
Prevent. Control. Prepare. Page 1 Prevent. Control. Prepare. Page 2 Page 3 Prevent. Control.
Prepare. Page 4 Global influenza strategy 2019-2030 ISBN 978-92-4-151532-0 © World Health …

Influenza vaccination modifies disease severity among community-dwelling adults hospitalized with influenza

C Arriola, S Garg, EJ Anderson, PA Ryan… - Clinical Infectious …, 2017 - academic.oup.com
Background We investigated the effect of influenza vaccination on disease severity in adults
hospitalized with laboratory-confirmed influenza during 2013− 14, a season in which …

Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination

J Lee, DR Boutz, V Chromikova, MG Joyce… - Nature medicine, 2016 - nature.com
Molecular understanding of serological immunity to influenza has been confounded by the
complexity of the polyclonal antibody response in humans. Here we used high-resolution …

Estimating the annual attack rate of seasonal influenza among unvaccinated individuals: a systematic review and meta-analysis

MP Somes, RM Turner, LJ Dwyer, AT Newall - Vaccine, 2018 - Elsevier
Introduction Seasonal influenza affects millions of people globally each year, causing
significant morbidity and mortality. However, there remains substantial uncertainty about the …

Prevention of respiratory syncytial virus infection in healthy adults by a single immunization of Ad26. RSV. preF in a human challenge study

J Sadoff, E De Paepe, J DeVincenzo… - The Journal of …, 2022 - academic.oup.com
Background Respiratory syncytial virus (RSV) is a significant cause of severe lower
respiratory tract disease in children and older adults, but has no approved vaccine. This …

Vaccine effectiveness against life-threatening influenza illness in US children

SM Olson, MM Newhams, NB Halasa… - Clinical Infectious …, 2022 - academic.oup.com
Background Predominance of 2 antigenically drifted influenza viruses during the 2019–2020
season offered an opportunity to assess vaccine effectiveness against life-threatening …