Preshaw PM, Taylor JJ. How has research into cytokine interactions and their role in driving
immune responses impacted our understanding of periodontitis? J Clin Periodontol 2011; …

For almost two decades, the Th1/Th2 paradigm has offered a productive conceptual
framework for investigating the pathogenesis of periodontitis. However, as with many other …

To characterize the roles of Porphyromonas gingivalis and its components in the disease
processes, we investigated the cytokine profile induced by live P. gingivalis, its …

Heat shock proteins (HSPs) have been reported to stimulate the immune system via innate
receptors. However, the role of HSPs as endogenous adjuvants has been challenged by …

Background Porphyromonas gingivalis is a major pathogen of periodontal disease that
affects a majority of adults worldwide. Increasing evidence shows that periodontal disease is …

We have demonstrated previously that tetra-acylated LPS derived from the oral bacterium,
Porphyromonas gingivalis, and penta-acylated msbB LPS derived from a mutant strain of …

Pro-inflammatory cytokine release (IL-8, IL-6, TNF-α, IL-1β) by peripheral blood neutrophils,
isolated from periodontitis patients (before/after therapy) and matched controls, was …

The lipopolysaccharide (LPS) and fimbriae of Porphyromonas gingivalis play important roles
in periodontal inflammation and pathogenesis. We investigated fimbriae and LPS from …

Oral microbiome dysbiosis mediates chronic periodontal disease, gut microbial dysbiosis,
and mucosal barrier disfunction that leads to steatohepatitis via the enterohepatic …

Infection with bacteria such as Chlamydia pneumonia, Helicobacter pylori or
Porphyromonas gingivalis may be triggering the secretion of inflammatory cytokines that …