The relative deficit of GDF15 in adolescent girls with PCOS can be changed into an abundance that reduces liver fat

F de Zegher, M Díaz, J Villarroya, M Cairó… - Scientific reports, 2021 - nature.com
A prime concern of young patients with Polycystic Ovary Syndrome (PCOS) is the control of
body adiposity, given their tendency to gain weight and/or their difficulty to lose weight …

Effects of half-dose spiomet treatment in girls with early puberty and accelerated bone maturation: a multicenter, randomized, placebo-controlled study protocol

J Bassols, F de Zegher, M Diaz, G Carreras-Badosa… - Trials, 2023 - Springer
Background A “mismatch” sequence of less prenatal weight gain and more postnatal weight
gain may lead to ectopic lipid accumulation, and trigger the development of early …

From adolescent PCOS to adult MAFLD: opposing effects of randomised interventions

F de Zegher, M Diaz, L Ibañez - BMJ Open …, 2021 - bmjopengastro.bmj.com
Asfari et al reported that nonalcoholic fatty liver disease (NAFLD) is fourfold more prevalent
in women with than without PCOS, and concluded that 'further studies are needed to assess …

多囊卵巢综合征患者血清S100A4 水平变化及其对多囊卵巢综合征的影响

任玉梅, 章秋, 胡红琳 - 临床荟萃, 2023 - huicui.hebmu.edu.cn
目的检测多囊卵巢综合征(polycystic ovary syndrome, PCOS) 患者血清S100A4 水平,
探讨S100A4 对多囊卵巢综合征发生发展的影响. 方法选取129 例于2021 年12 月—2023 年6 …

[HTML][HTML] Unraveling the Interplay between Nonalcoholic Fatty Liver Disease and Polycystic Ovary Syndrome in Adolescents: Pathogenesis, Prevalence, and …

K Półkośnik, A Łebkowska, I Kowalska… - … Medical Journal of …, 2023 - ncbi.nlm.nih.gov
Background With the expanding understanding of conditions contributing to heightened
cardiovascular risk, emerging pathologies like nonalcoholic fatty liver disease (NAFLD) and …

002 The sequence of central obesity, rapid maturation, and polycystic ovary syndrome in [LDQUO] mismatch [RDQUO] girls

F de Zegher, L Ibáñez - European Journal of Obstetrics and Gynecology …, 2022 - ejog.org
The timing of puberty varies widely in the population and is determined by a complex mix of
inherited genetic variation and environmental influences–nature vs nurture. In this talk will …

001 Genetics of menarche

J Perry - European Journal of Obstetrics and Gynecology and …, 2022 - ejog.org
The timing of puberty varies widely in the population and is determined by a complex mix of
inherited genetic variation and environmental influences–nature vs nurture. In this talk will …

[PDF][PDF] The sequence of central obesity, rapid maturation, and PCOS in “mismatch” girls with reduced prenatal weight gain and augmented postnatal weight gain La …

F de Zegher, L Ibáñez - Rev Esp Endocrinol Pediatr, 2021 - endocrinologiapediatrica.org
A variable mix of genetic, epigenetic and environmental factors may result in a “mismatch”
sequence of reduced prenatal weight gain (with reduced subcutaneous adipogenesis, and …

[引用][C] 007 Pharmacological treatment of PCOS in adolescence

F de Zegher, L Ibáñez - European Journal of Obstetrics and Gynecology …, 2022 - ejog.org
Polycystic ovary syndrome (PCOS) is a complex heterogenous disorder characterized by
hyperandrogenism and chronic anovulation. Six (6%) to 20% of reproductive aged women …