Regulation and function of Spalt proteins during animal development
The genes of the spalt (sal) family play fundamental roles during animal development. The
two members of this family in Drosophila, spalt (sal) and spalt-related (salr) encode Zn-finger …
two members of this family in Drosophila, spalt (sal) and spalt-related (salr) encode Zn-finger …
[HTML][HTML] The vertebrate spalt genes in development and disease
D Sweetman, A Münsterberg - Developmental biology, 2006 - Elsevier
The spalt proteins are encoded by a family of evolutionarily conserved genes found in
species as diverse as Drosophila, C. elegans and vertebrates. In humans, mutations in …
species as diverse as Drosophila, C. elegans and vertebrates. In humans, mutations in …
Mutations in the SALL1 putative transcription factor gene cause Townes-Brocks syndrome
J Kohlhase, A Wischermann, H Reichenbach… - Nature …, 1998 - nature.com
Abstract Townes-Brocks syndrome (IBS, OMIM# 107480) is a rare autosomal-dominant
malformation syndrome with a combination of anal, renal, limb and ear anomalies1 …
malformation syndrome with a combination of anal, renal, limb and ear anomalies1 …
[HTML][HTML] Fluorescence-and magnetic-activated cell sorting strategies to isolate and enrich human spermatogonial stem cells
H Valli, M Sukhwani, SL Dovey, KA Peters, J Donohue… - Fertility and sterility, 2014 - Elsevier
Objective To determine the molecular characteristics of human spermatogonia and optimize
methods to enrich spermatogonial stem cells (SSCs). Design Laboratory study using human …
methods to enrich spermatogonial stem cells (SSCs). Design Laboratory study using human …
Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal …
J Kohlhase, L Schubert, M Liebers, A Rauch… - Journal of medical …, 2003 - jmg.bmj.com
We have recently shown that Okihiro syndrome results from mutation in the putative zinc
finger transcription factor gene SALL4 on chromosome 20q13. 13-13.2. There is …
finger transcription factor gene SALL4 on chromosome 20q13. 13-13.2. There is …
[HTML][HTML] Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex
J Lu, H Jeong, N Kong, Y Yang, J Carroll, HR Luo… - PloS one, 2009 - journals.plos.org
Background The embryonic stem cell (ESC) factor, SALL4, plays an essential role in both
development and leukemogenesis. It is a unique gene that is involved in self-renewal in …
development and leukemogenesis. It is a unique gene that is involved in self-renewal in …
[HTML][HTML] SALL4 expression in gonocytes and spermatogonial clones of postnatal mouse testes
The spermatogenic lineage is established after birth when gonocytes migrate to the
basement membrane of seminiferous tubules and give rise to spermatogonial stem cells …
basement membrane of seminiferous tubules and give rise to spermatogonial stem cells …
[HTML][HTML] Regionalized metabolic activity establishes boundaries of retinoic acid signalling
T Hollemann, Y Chen, H Grunz, T Pieler - The EMBO journal, 1998 - embopress.org
The competence of a cell to respond to the signalling molecule retinoic acid (RA) is thought
to depend largely on its repertoire of cognate zinc finger nuclear receptors. XCYP26 is an …
to depend largely on its repertoire of cognate zinc finger nuclear receptors. XCYP26 is an …
SALL4 mutations in Okihiro syndrome (Duane‐radial ray syndrome), acro‐renal‐ocular syndrome, and related disorders
J Kohlhase, D Chitayat, D Kotzot, S Ceylaner… - Human …, 2005 - Wiley Online Library
Okihiro/Duane‐radial ray syndrome (DRRS) is an autosomal dominant condition
characterized by radial ray defects and Duane anomaly (a form of strabismus). Other …
characterized by radial ray defects and Duane anomaly (a form of strabismus). Other …
[HTML][HTML] Increased XRALDH2 activity has a posteriorizing effect on the central nervous system of Xenopus embryos
Y Chen, N Pollet, C Niehrs, T Pieler - Mechanisms of development, 2001 - Elsevier
Retinoic acid (RA) metabolizing enzymes play important roles in RA signaling during
vertebrate embryogenesis. We have previously reported on a RA degrading enzyme …
vertebrate embryogenesis. We have previously reported on a RA degrading enzyme …