Clear cell renal cell carcinoma (ccRCC) is the most frequent histological kidney cancer
subtype. Over the last decade, significant progress has been made in identifying the genetic …

Simple Summary Drug resistance remains one of the major problems in cancer therapy and
is responsible for up to 90% of cancer-related deaths. It exists across all types of cancer and …

Renal cell carcinoma (RCC) is the seventh most common cancer in men and the ninth most
common cancer in women worldwide. There is plenty of evidence about the role of the …

Introduction Lipidomics focuses on the in-depth analysis of lipids, which are crucial
macromolecules involved in a wide range of metabolic pathways. The increased …

Globally, clear-cell renal cell carcinoma (ccRCC) represents the most prevalent type of
kidney cancer. Surgery plays a key role in the treatment of this cancer, although one third of …

Mucin1 (MUC1), a glycoprotein associated with an aggressive cancer phenotype and
chemoresistance, is aberrantly overexpressed in a subset of clear cell renal cell carcinoma …

The crosstalk among the complement system, immune cells, and mediators of inflammation
provides an efficient mechanism to protect the organism against infections and support the …

Constituent of innate immunity, complement is present in the tumor microenvironment. The
functions of complement include clearance of pathogens and maintenance of homeostasis …

Clear cell renal cell carcinoma (ccRCC) is fundamentally a metabolic disease. Given the
importance of lipids in many cellular processes, in this study we delineated a lipidomic …

The complement system plays a complex role in cancer. In clear cell renal cell carcinoma
(ccRCC), local production of complement proteins drives tumor progression, but the …