Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …

The deposition of proteins in the form of amyloid fibrils and plaques is the characteristic
feature of more than 20 degenerative conditions affecting either the central nervous system …

Alzheimer's disease is the leading cause of dementia in the elderly and is defined by two
pathological hallmarks; the accumulation of aggregated amyloid beta and excessively …

One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

A hypothetical model of Alzheimer's disease (AD) as a uniquely human brain disorder
rooted in its exceptional process of myelination is presented. Cortical regions with the most …

Although amyloid‐β peptide (Aβ) is the neurotoxic species implicated in the pathogenesis of
Alzheimer's disease (AD), mechanisms through which intracellular Aβ impairs cellular …

There is a growing body of evidence to support a role for oxidative stress in Alzheimer's
disease (AD), with increased levels of lipid peroxidation, DNA and protein oxidation …

Oxidative stress has been implicated as playing a role in neurodegenerative disorders, such
as ischemic stroke, Alzheimer's, Huntington's, and Parkinson's disease. Persuasive …

Alzheimer's disease is the most common form of dementia in the elderly, and it is
characterized by elevated brain iron levels and accumulation of copper and zinc in cerebral …

We have developed novel aldazine-based colorimetric chemosensors for Cu2+ and Fe3+.
The aldazine ligands were synthesized by simple condensation of 4-diethylamino …