Extracellular vesicles as therapeutic resources in the clinical environment

J Sanz-Ros, C Mas-Bargues, N Romero-García… - International journal of …, 2023 - mdpi.com
The native role of extracellular vesicles (EVs) in mediating the transfer of biomolecules
between cells has raised the possibility to use them as therapeutic vehicles. The …

Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context

A Esmaeili, M Alini, M Baghaban Eslaminejad… - Stem Cell Research & …, 2022 - Springer
Extracellular vesicles (EVs) are advanced therapeutic strategies that can be used to
efficiently treat diseases. Promising features of EVs include their innate therapeutic …

Isolation of Aloe saponaria-Derived Extracellular Vesicles and Investigation of Their Potential for Chronic Wound Healing

M Kim, JH Park - Pharmaceutics, 2022 - mdpi.com
A chronic wound is caused by a failure to progress through the normal phases of wound
repair in an orderly and timely manner. To induce skin regeneration while inhibiting chronic …

Endothelial extracellular vesicles: from keepers of health to messengers of disease

A Mathiesen, T Hamilton, N Carter, M Brown… - International Journal of …, 2021 - mdpi.com
Endothelium has a rich vesicular network that allows the exchange of macromolecules
between blood and parenchymal cells. This feature of endothelial cells, along with their …

Extracellular vesicles and intercellular communication: Challenges for in vivo molecular imaging and tracking

D Petroni, C Fabbri, S Babboni, L Menichetti, G Basta… - Pharmaceutics, 2023 - mdpi.com
Extracellular vesicles (EVs) are a heterogeneous class of cell-derived membrane vesicles
released by various cell types that serve as mediators of intercellular signaling. When …

Exploiting the natural properties of extracellular vesicles in targeted delivery towards specific cells and tissues

P Lara, AB Chan, LJ Cruz, AFG Quest, MJ Kogan - Pharmaceutics, 2020 - mdpi.com
Extracellular vesicles (EVs) are important mediators of intercellular communication that
participate in many physiological/pathological processes. As such, EVs have unique …

[HTML][HTML] Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells

L Ottaviani, RP Juni, RC de Abreu, M Sansonetti… - Molecular Therapy, 2022 - cell.com
As mediators of intercellular communication, extracellular vesicles containing molecular
cargo, such as microRNAs, are secreted by cells and taken up by recipient cells to influence …

Comparative analysis of normoxia-and hypoxia-modified extracellular vesicle therapy in function, perfusion, and collateralization in chronically ischemic myocardium

SA Sabe, CM Xu, BA Potz, A Malhotra, M Sabra… - International Journal of …, 2023 - mdpi.com
We have previously shown that normoxia serum-starved extracellular vesicle (EV) therapy
improves myocardial function, perfusion, and angiogenesis in a swine model of chronic …

Hypoxia and TNF‐alpha modulate extracellular vesicle release from human induced pluripotent stem cell‐derived cardiomyocytes

M Viola, MP Bebelman, RGC Maas… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs) have emerged as important mediators of intercellular
communication in the heart under homeostatic and pathological conditions, such as …

MicroRNA profile of extracellular vesicles released by Müller glial cells

WDB Lamb, K Eastlake, J Luis, NA Sharif… - Frontiers in Cellular …, 2024 - frontiersin.org
Introduction As with any other radial glia in the central nervous system, Müller glia derive
from the same neuroepithelial precursors, perform similar functions, and exhibit neurogenic …