Phosphodiesterases (PDEs), enzymes that degrade 3′, 5′-cyclic nucleotides, are being
pursued as therapeutic targets for several diseases, including those affecting the nervous …

Estimating the effects of variants found in disease driver genes opens the door to
personalized therapeutic opportunities. Clinical associations and laboratory experiments …

Cannabinoids, mainly cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), are the most
studied group of compounds obtained from Cannabis sativa because of their several …

An early symptom of Alzheimer's disease (AD) is an impaired sense of smell, for which the
molecular basis remains elusive. Here, we generated human olfactory neurosphere-derived …

Macrophage expansion and inflammatory responses are involved in induction of cardiac
remodeling. Resveratrol has strong anti-inflammatory effects, however its effect on …

Striated myocytes compose about half of the cells of the heart, while contributing the majority
of the heart's mass and volume. In response to increased demands for pumping power …

Myocardial ischemia–reperfusion (I/R) injury significantly alters heart function following
infarct and increases the risk of heart failure. Many studies have sought to preserve …

Abstract Adenosine 3′, 5′-cyclic monophosphate (cAMP) acts as a second messenger
that is involved in the regulation of a plethora of processes. The activation of cAMP signaling …

An early symptom of Alzheimer's disease (AD) is an impaired sense of smell, for which the
molecular basis remains elusive. Here, we generated human olfactory neurosphere-derived …

Cardiovascular diseases (CVDs) are a leading cause of death in the United States and the
world. The global costs for CVDs is increasing at alarming rate with an expected $180 billion …