Abstract Structure-specific endonucleases (SSEs) have key roles in DNA replication,
recombination and repair, and emerging roles in transcription. These enzymes have …

The complete and faithful duplication of the genome is an essential prerequisite for
proliferating cells to maintain genome integrity. This objective is greatly challenged by DNA …

DNA double-strand breaks (DSBs) can be repaired by several pathways. In eukaryotes, DSB
repair pathway choice occurs at the level of DNA end resection and is controlled by the cell …

Abstract The Dbf4-dependent kinase Cdc7 (DDK) regulates DNA replication initiation by
phosphorylation of the MCM double hexamer (MCM-DH) to promote helicase activation …

Bloom's syndrome is caused by inactivation of the BLM helicase, which functions with
TOP3A and RMI1-2 (BTR complex) to dissolve recombination intermediates and avoid …

The synaptonemal complex (SC) is a proteinaceous macromolecular assembly that forms
during meiotic prophase I and mediates adhesion of paired homologous chromosomes …

Common fragile sites (CFSs) are genomic regions that display gaps and breaks in human
metaphase chromosomes under replication stress and are often deleted in cancer cells. We …

The CDC7 kinase is essential for the activation of DNA replication origins and has been
implicated in the replication stress response. Using a highly specific chemical inhibitor and a …

The SLX4/FANCP tumor suppressor has emerged as a key player in the maintenance of
genome stability, making pivotal contributions to the repair of interstrand cross-links …

Simple Summary To ensure the maintenance of genetic stability prior to cell division a cell's
complement of chromosomes must be duplicated. This requires not only the replication of …