Conventional cancer therapies suffer from severe off-target effects because most of them
target critical facets of cells that are generally shared by all rapidly proliferating cells. The …

One of the basic trace elements for the structure and metabolism of human tissue is copper.
However, as a heavy metal, excessive intake or abnormal accumulation of copper in the …

As an essential nutrient, copper's redox properties are both beneficial and toxic to cells.
Therefore, leveraging the characteristics of copper-dependent diseases or using copper …

Copper (Cu) is an essential micronutrient for the correct development of eukaryotic
organisms. This metal plays a key role in many cellular and physiological activities …

Simple Summary Medulloblastoma is the most common malignant brain tumor in the
pediatric population. Despite the utilization of aggressive treatment modalities, including …

Cuproptosis is a newly identified form of cell death induced by excessive copper (Cu)
accumulation within cells. Mechanistically, cuproptosis results from Cu-induced aggregation …

Colorectal cancer is one of the most common malignancies causing the majority of cancer-
related deaths. There is an urgent need to develop new anticancer modalities. Recently …

Few prognostic biomarkers exist for lung squamous cell carcinoma (LUSC), which has a
poor five-year survival rate. Using bioinformatics, this study evaluated NPLOC4 as a …

Drug efficacy determined in preclinical research is difficult to transfer to clinical practice. This
is mainly due to the use of oversimplified models omitting the effect of the tumor …

Cancer is a major global health issue. Effective therapeutic strategies can prolong patients'
survival and reduce the costs of treatment. Drug repurposing, which identifies new …