Obesity, adipose tissue and vascular dysfunction

M Koenen, MA Hill, P Cohen, JR Sowers - Circulation research, 2021 - Am Heart Assoc
Cardiovascular diseases are the leading cause of death worldwide. Overweight and obesity
are strongly associated with comorbidities such as hypertension and insulin resistance …

[HTML][HTML] Pathophysiology of type 2 diabetes mellitus

U Galicia-Garcia, A Benito-Vicente, S Jebari… - International journal of …, 2020 - mdpi.com
Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …

[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease

A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

The complex role of adipokines in obesity, inflammation, and autoimmunity

EB Taylor - Clinical Science, 2021 - portlandpress.com
The global obesity epidemic is a major contributor to chronic disease and disability in the
world today. Since the discovery of leptin in 1994, a multitude of studies have characterized …

[HTML][HTML] Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines

SS Rao, Y Hu, PL Xie, J Cao, ZX Wang, JH Liu, H Yin… - Bone research, 2018 - nature.com
Osteoporosis is a frequent complication of chronic inflammatory diseases and increases in
the pro-inflammatory cytokines make an important contribution to bone loss by promoting …

Adipose tissue‐derived omentin‐1 function and regulation

T Watanabe, K Watanabe‐Kominato… - Comprehensive …, 2011 - Wiley Online Library
Omentin‐1, also known as intelectin‐1, is a recently identified novel adipocytokine of 313
amino acids, which is expressed in visceral (omental and epicardial) fat as well as …

Role of adipokines (omentin and visfatin) in coronary artery disease

S Ali, R Alam, H Ahsan, S Khan - Nutrition, metabolism and cardiovascular …, 2023 - Elsevier
Aims Adipose tissue is considered as an endocrine organ that releases bioactive factors
known as adipokines which contribute to the pathogenesis of rotundity-linked metabolic and …

[HTML][HTML] Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization

CY Ko, YY Lin, D Achudhan, JW Chang… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is a prevalent joint disease commonly associated with aging and obesity,
which can lead to pain, stiffness, joint dysfunction, and disability. Omentin-1 (also called …

Adipokines as an important link between hidradenitis suppurativa and obesity: a narrative review

PK Krajewski, Ł Matusiak… - British Journal of …, 2023 - academic.oup.com
Hidradenitis suppurativa (HS) is a chronic, recurrent, debilitating disorder of the
pilosebaceous unit. Although its pathophysiology is not fully explained, inflammation seems …

[HTML][HTML] The influence of biologically active substances secreted by the adipose tissue on endometrial cancer

K Michalczyk, N Niklas, M Rychlicka… - Diagnostics, 2021 - mdpi.com
Endometrial cancer is one of the most frequently diagnosed gynecological neoplasms in
developed countries and its incidence is rising. Usually, it is diagnosed in the early stages of …