Inducing immune tolerance with dendritic cell-targeting nanomedicines

A Cifuentes-Rius, A Desai, D Yuen… - Nature …, 2021 - nature.com
Induced tolerogenic dendritic cells are a powerful immunotherapy for autoimmune disease
that have shown promise in laboratory models of disease and early clinical trials. In contrast …

Design challenges in polymeric scaffolds for tissue engineering

MI Echeverria Molina, KG Malollari… - … in Bioengineering and …, 2021 - frontiersin.org
Numerous surgical procedures are daily performed worldwide to replace and repair
damaged tissue. Tissue engineering is the field devoted to the regeneration of damaged …

Understanding nanomaterial–liver interactions to facilitate the development of safer nanoapplications

J Li, C Chen, T Xia - Advanced Materials, 2022 - Wiley Online Library
Nanomaterials (NMs) are widely used in commercial and medical products, such as
cosmetics, vaccines, and drug carriers. Exposure to NMs via various routes such as dermal …

2D and 3D electrospinning technologies for the fabrication of nanofibrous scaffolds for skin tissue engineering: A review

A Keirouz, M Chung, J Kwon… - Wiley …, 2020 - Wiley Online Library
This review provides insights into the current advancements in the field of electrospinning,
focusing on its applications for skin tissue engineering. Furthermore, it reports the …

Strategies for durable β cell replacement in type 1 diabetes

TM Brusko, HA Russ, CL Stabler - Science, 2021 - science.org
Technological advancements in blood glucose monitoring and therapeutic insulin
administration have improved the quality of life for people with type 1 diabetes. However …

Advanced strategies for modulation of the material–macrophage interface

L Davenport Huyer, S Pascual‐Gil… - Advanced Functional …, 2020 - Wiley Online Library
Biomaterials are becoming increasingly crucial for healthcare solutions, with extensive use
in the field of tissue engineering and drug delivery. After implantation, biomaterials trigger an …

T lymphocytes as critical mediators in tissue regeneration, fibrosis, and the foreign body response

KM Adusei, TB Ngo, K Sadtler - Acta Biomaterialia, 2021 - Elsevier
Research on the foreign body response (FBR) to biomaterial implants has been focused on
the roles that the innate immune system has on mediating tolerance or rejection of implants …

Engineered immunomodulatory accessory cells improve experimental allogeneic islet transplantation without immunosuppression

X Wang, K Wang, M Yu, D Velluto, X Hong, B Wang… - Science …, 2022 - science.org
Islet transplantation has been established as a viable treatment modality for type 1 diabetes.
However, the side effects of the systemic immunosuppression required for patients often …

Modulating the foreign body response of implants for diabetes treatment

BN Kharbikar, GS Chendke, TA Desai - Advanced drug delivery reviews, 2021 - Elsevier
Diabetes Mellitus is a group of diseases characterized by high blood glucose levels due to
patients' inability to produce sufficient insulin. Current interventions often require implants …

Pushing the natural frontier: Progress on the integration of biomaterial cues toward combinatorial biofabrication and tissue engineering

CF Guimarães, AP Marques, RL Reis - Advanced Materials, 2022 - Wiley Online Library
The engineering of fully functional, biological‐like tissues requires biomaterials to direct
cellular events to a near‐native, 3D niche extent. Natural biomaterials are generally seen as …