Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st
century. It is a well-recognized multifactorial health problem contributes significantly to high …

Privileged structures have been widely used as an effective template for the research and
discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and …

Abstract α-Glucosidase enzyme inhibition is an effective therapeutic decorum in the
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …

Diabetes is one of the major diseases worldwide and is the third leading cause of death in
the United States. Anti-diabetic drugs are used in the treatment of diabetes mellitus to control …

In this study, potent coumarin derivatives containing oxime ester 1∼ 28 as α-glucosidase
inhibitors were developed through a stepwise structure optimization, and the structure …

Inhibiting α-glucosidase is a reliable method for reducing blood sugar levels in diabetic
individuals. Bis (dimethylamino) benzophenone derivatives 1–27 were synthesized from bis …

Hybrid molecules, furnished by combining two or more pharmacophores is an emerging
concept in the field of medicinal chemistry and drug discovery that has attracted substantial …

In the present study, a series of 2, 3-dihydro-1, 5-benzothiazepine derivatives 1B–14B has
been synthesized sand characterized by various spectroscopic techniques. The enzyme …

The prevalence of diabetes mellitus is on the rise, which demands the identification of novel
antidiabetic drugs. There is a need for safer and more effective alternatives because the …

The high incidence of diabetes mellitus has caused widespread concern around the world,
and has quickly become one of the most prevalent and costly chronic diseases. Alpha …