The structural and functional complexity of the integrative hypothalamus

H Fong, J Zheng, D Kurrasch - Science, 2023 - science.org
The hypothalamus (“hypo” meaning below, and “thalamus” meaning bed) consists of
regulatory circuits that support basic life functions that ensure survival. Sitting at the interface …

Ontogenetic rules for the molecular diversification of hypothalamic neurons

M Benevento, T Hökfelt, T Harkany - Nature reviews neuroscience, 2022 - nature.com
The hypothalamus is an evolutionarily conserved endocrine interface that, among other
roles, links central homeostatic control to adaptive bodily responses by releasing hormones …

Detecting signatures of selection on gene expression

PD Price, DH Palmer Droguett, JA Taylor… - Nature Ecology & …, 2022 - nature.com
A substantial amount of phenotypic diversity results from changes in gene expression levels
and patterns. Understanding how the transcriptome evolves is therefore a key priority in …

Fourth report on chicken genes and chromosomes 2022

J Smith, JM Alfieri, N Anthony, P Arensburger… - … and genome research, 2023 - karger.com
The chicken continues to hold its position as a leading model organism within many areas of
research, as well as being a major source of protein for human consumption. The First …

[HTML][HTML] Cortico-thalamic development and disease: from cells, to circuits, to schizophrenia

MM Angulo Salavarria, C Dell'Amico… - Frontiers in …, 2023 - frontiersin.org
The human brain is the most complex structure generated during development. Unveiling
the ontogenesis and the intrinsic organization of specific neural networks may represent a …

A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus

K Chinnaiya, S Burbridge, A Jones, DW Kim, E Place… - Elife, 2023 - elifesciences.org
The tuberal hypothalamus controls life-supporting homeostatic processes, but despite its
fundamental role, the cells and signalling pathways that specify this unique region of the …

Modeling hypothalamic pathophysiology in vitro for metabolic, circadian, and sleep disorders

H Leal, C Carvalhas-Almeida, AR Álvaro… - Trends in Endocrinology …, 2024 - cell.com
The hypothalamus, a small and intricate brain structure, orchestrates numerous
neuroendocrine functions through specialized neurons and nuclei. Disruption of this …

[HTML][HTML] Dorsoventral arrangement of lateral hypothalamus populations in the mouse hypothalamus: A prosomeric genoarchitectonic analysis

C Diaz, MM de la Torre, JLR Rubenstein… - Molecular …, 2023 - Springer
The lateral hypothalamus (LH) has a heterogeneous cytoarchitectonic organization that has
not been elucidated in detail. In this work, we analyzed within the framework of the …

[HTML][HTML] Accurate staging of chick embryonic tissues via deep learning of salient features

I Groves, J Holmshaw, D Furley, E Manning… - …, 2023 - journals.biologists.com
Recent work shows that the developmental potential of progenitor cells in the HH10 chick
brain changes rapidly, accompanied by subtle changes in morphology. This demands …

Manipulation of Signal Gradient and Transcription Factors Recapitulates: Multiple Hypothalamic Identities

M Yamamoto, ALC Ong, T Shinozuka, M Shirai… - Stem Cells, 2023 - academic.oup.com
During development, the hypothalamus emerges from the ventral diencephalon and is
regionalized into several distinct functional domains. Each domain is characterized by a …