The structural and functional complexity of the integrative hypothalamus
H Fong, J Zheng, D Kurrasch - Science, 2023 - science.org
The hypothalamus (“hypo” meaning below, and “thalamus” meaning bed) consists of
regulatory circuits that support basic life functions that ensure survival. Sitting at the interface …
regulatory circuits that support basic life functions that ensure survival. Sitting at the interface …
Ontogenetic rules for the molecular diversification of hypothalamic neurons
The hypothalamus is an evolutionarily conserved endocrine interface that, among other
roles, links central homeostatic control to adaptive bodily responses by releasing hormones …
roles, links central homeostatic control to adaptive bodily responses by releasing hormones …
Detecting signatures of selection on gene expression
A substantial amount of phenotypic diversity results from changes in gene expression levels
and patterns. Understanding how the transcriptome evolves is therefore a key priority in …
and patterns. Understanding how the transcriptome evolves is therefore a key priority in …
Fourth report on chicken genes and chromosomes 2022
The chicken continues to hold its position as a leading model organism within many areas of
research, as well as being a major source of protein for human consumption. The First …
research, as well as being a major source of protein for human consumption. The First …
[HTML][HTML] Cortico-thalamic development and disease: from cells, to circuits, to schizophrenia
MM Angulo Salavarria, C Dell'Amico… - Frontiers in …, 2023 - frontiersin.org
The human brain is the most complex structure generated during development. Unveiling
the ontogenesis and the intrinsic organization of specific neural networks may represent a …
the ontogenesis and the intrinsic organization of specific neural networks may represent a …
A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus
K Chinnaiya, S Burbridge, A Jones, DW Kim, E Place… - Elife, 2023 - elifesciences.org
The tuberal hypothalamus controls life-supporting homeostatic processes, but despite its
fundamental role, the cells and signalling pathways that specify this unique region of the …
fundamental role, the cells and signalling pathways that specify this unique region of the …
Modeling hypothalamic pathophysiology in vitro for metabolic, circadian, and sleep disorders
H Leal, C Carvalhas-Almeida, AR Álvaro… - Trends in Endocrinology …, 2024 - cell.com
The hypothalamus, a small and intricate brain structure, orchestrates numerous
neuroendocrine functions through specialized neurons and nuclei. Disruption of this …
neuroendocrine functions through specialized neurons and nuclei. Disruption of this …
[HTML][HTML] Dorsoventral arrangement of lateral hypothalamus populations in the mouse hypothalamus: A prosomeric genoarchitectonic analysis
C Diaz, MM de la Torre, JLR Rubenstein… - Molecular …, 2023 - Springer
The lateral hypothalamus (LH) has a heterogeneous cytoarchitectonic organization that has
not been elucidated in detail. In this work, we analyzed within the framework of the …
not been elucidated in detail. In this work, we analyzed within the framework of the …
[HTML][HTML] Accurate staging of chick embryonic tissues via deep learning of salient features
I Groves, J Holmshaw, D Furley, E Manning… - …, 2023 - journals.biologists.com
Recent work shows that the developmental potential of progenitor cells in the HH10 chick
brain changes rapidly, accompanied by subtle changes in morphology. This demands …
brain changes rapidly, accompanied by subtle changes in morphology. This demands …
Manipulation of Signal Gradient and Transcription Factors Recapitulates: Multiple Hypothalamic Identities
M Yamamoto, ALC Ong, T Shinozuka, M Shirai… - Stem Cells, 2023 - academic.oup.com
During development, the hypothalamus emerges from the ventral diencephalon and is
regionalized into several distinct functional domains. Each domain is characterized by a …
regionalized into several distinct functional domains. Each domain is characterized by a …