Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the
brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM) …

Tuberculous meningitis (TBM), the most severe form of tuberculosis, causes death in
approximately 25% cases despite antibiotic therapy, and half of survivors are left with …

Tuberculous meningitis (TB meningitis) is the most devastating form of tuberculosis (TB) and
there is a critical need to optimize treatment. Linezolid is approved for multidrug resistant TB …

Background Linezolid is evaluated in novel treatment regimens for tuberculous meningitis
(TBM). Linezolid pharmacokinetics have not been characterized in this population …

Most drugs used in the treatment of Tuberculous Meningitis have limited CNS penetration
thereby limiting efficacy. CSF penetration of linezolid is 80–100%. The study was a …

Neurotuberculosis has the highest morbidity and mortality risk of all forms of extrapulmonary
tuberculosis (TB). Early treatment is paramount, but establishing diagnosis are challenging …

Tuberculosis meningitis (TBM) is essentially treated with the first-line regimen used against
pulmonary tuberculosis, with a prolonged continuation phase. However, clinical outcomes …

Background The duration and regimen of tuberculosis (TB) treatment is currently based
predominantly on whether the M. tuberculosis (Mtb) strain is drug-sensitive (DS) or multidrug …

Treatment of tuberculous meningitis: Overdue for concerted action Treatment of tuberculous
meningitis: Overdue for concerted action Tuberculosis (Edinb). 2023 Sep;142:102361. doi …

Tuberculous meningitis treatment outcomes are poor and alternative regimens are under
investigation. Reliable methods to measure drug concentrations in cerebrospinal fluid are …