Hepatotoxic microcystins (MCs) are the most widespread class of cyanotoxins and the one
that has most often been implicated in cyanobacterial toxicosis. One of the main challenges …

There is a continuous need for iterative cycles of antibiotic discovery and development to
deal with the selection of resistant pathogens that emerge as therapeutic application of an …

Emerging resistance to currently used antibiotics is a global public health crisis. Because
most of the biosynthetic capacity within the bacterial kingdom has remained silent in …

Microbial natural products represent a rich resource of pharmaceutically and industrially
important compounds. Genome sequencing has revealed that the majority of natural …

Filamentous fungi produce a multitude of low molecular weight bioactive compounds. The
increasing number of fungal genome sequences impressively demonstrated that their …

Covering: up to July 2015 Nonribosomal peptides are amongst the most widespread and
structurally diverse secondary metabolites in nature with many possessing bioactivity that …

Many thousands of small molecule natural products with interesting biological activities are
polyketides (PK), nonribosomal peptides (NRP), or hybrids thereof (ie, PK-NRP hybrids) …

▪ Abstract Bacteria and fungi use large multifunctional enzymes, the so-called nonribosomal
peptide synthetases (NRPSs), to produce peptides of broad structural and biological activity …

The regulatory logic of siderophore biosynthetic genes in bacteria involves the universal
repressor Fur, which acts together with iron as a negative regulator. However in other …

Despite their remarkable biosynthetic potential, Bacillus subtilis have been widely
overlooked. However, their capability to withstand harsh conditions (extreme temperature …