Hepatitis C virus (HCV) is a major cause of liver diseases including liver cirrhosis and
hepatocellular carcinoma. Approximately 3% of the world population is infected with HCV …

One of the core standards of biochemistry is that the function of a protein relies on its 3D
structure. This idea posits that all the information required for a protein to perform its …

The NS5A protein of hepatitis C virus is believed to be an integral part of the viral replicase.
Despite extensive investigation, the role of this protein remains elusive. Only limited …

The non-structural 5A (NS5A) protein of hepatitis C virus (HCV) has been the subject of
intensive research over the last decade. It is generally accepted that NS5A is a pleiotropic …

Hepatitis C virus (HCV) causes acute and chronic hepatitis which can eventually lead to
permanent liver damage, hepatocellular carcinoma and death. Currently, there is no vaccine …

The development of hepatocellular carcinoma (HCC) in persons who are persistently
infected with hepatitis C virus (HCV) is a growing problem worldwide. Current antiviral …

Hepatitis C virus (HCV) establishes a persistent infection, with up to 80% of infected
individuals proceeding to chronic hepatitis, which in many cases may result in liver cirrhosis …

The NS5A protein of hepatitis C virus (HCV) plays an important but undefined role in viral
RNA replication. NS5A has been proposed to be a three-domain protein, and the crystal …

The hepatitis C virus (HCV) nonstructural protein (NS) 5A is a phosphoprotein that
associates with various cellular proteins and participates in the replication of the HCV …

The hepatitis C virus (HCV) nonstructural 5A (NS5A) phosphoprotein has been intensely
studied due to its ability to subvert the host interferon-induced antiviral response. However …