Computer-aided drug discovery has been around for decades, although the past few years
have seen a tectonic shift towards embracing computational technologies in both academia …

The development of late-stage functionalization (LSF) methodologies, particularly C–H
functionalization, has revolutionized the field of organic synthesis. Over the past decade …

Designing new medicines more cheaply and quickly is tightly linked to the quest of exploring
chemical space more widely and efficiently. Chemical space is monumentally large, but …

Technological advances and practical applications of the chemical space concept in drug
discovery, natural product research, and other research areas have attracted the scientific …

In the quest for sustainable processes, the selection of resources and catalysts is of central
importance. Carboxylic acids, which are abundant, stable and ideally biobased feedstocks …

The development of DNA-encoded library (DEL) technology introduced new challenges for
the analysis of chemical libraries. It is often useful to consider a chemical library as a stand …

Introduction Late-stage functionalization (LSF) allows for the introduction of new chemical
groups toward the end of a synthetic sequence, which means new molecules can be rapidly …

Introduction Chemical space is a general conceptual framework that addresses the diversity
of molecules and it has various applications. Moreover, chemical space is a cornerstone of …

A method for the generation of tertiary carbanions via a deaminative radical‐polar crossover
is reported using redox active imines from α‐tertiary primary amines. A variety of benzylic …

Aryl bromides are known to be challenging substrates in the decarboxylative cross-
electrophile coupling with redox-active NHP esters–the majority of such processes utilize …