Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

Networks of molecular regulators are often the primary objects of focus in the study of gene
regulation, with the machinery of protein synthesis tacitly relegated to the background …

Predicting interactions between proteins and other biomolecules solely based on structure
remains a challenge in biology. A high-level representation of protein structure, the …

Through advanced mechanistic modeling and the generation of large high-quality datasets,
machine learning is becoming an integral part of understanding and engineering living …

Background Microbial-driven decomposition of plant residues is integral to carbon
sequestration in terrestrial ecosystems. Actinobacteria, one of the most widely distributed …

Metabolite-protein interactions control a variety of cellular processes, thereby playing a
major role in maintaining cellular homeostasis. Metabolites comprise the largest fraction of …

Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …

Overflow metabolism refers to the seemingly wasteful strategy in which cells use
fermentation instead of the more efficient respiration to generate energy, despite the …

Metabolism is the sum of the enzyme‐dependent chemical reactions, which produces
energy in catabolic process and synthesizes biomass in anabolic process, exhibiting high …

Adenosine triphosphate (ATP) plays fundamental roles in cellular biochemistry and was
recently discovered to function as a biological hydrotrope. Here, we use mass spectrometry …