Background Anti-cancer therapy is often a cause of premature ovarian insufficiency and
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …

Cancer treatments are increasingly effective, but can result in iatrogenic premature ovarian
insufficiency. Ovarian tissue cryopreservation is the only option available to preserve fertility …

Primary ovarian insufficiency (POI) is a clinical syndrome of ovarian dysfunction
characterized by premature exhaustion of primordial follicles. POI causes infertility, severe …

Female fertility and offspring health are critically dependent on an adequate supply of high-
quality oocytes, the majority of which are maintained in the ovaries in a unique state of …

Cancer treatment, such as chemotherapy, induces early ovarian follicular depletion and
subsequent infertility. In order to protect gametes from the gonadotoxic effects of …

The poultry ovary is used as a classic model to study ovarian biology and ovarian cancer.
Stress factors induced oxidative stress to cause follicle atresia, which may be a fundamental …

Cyclophosphamide and doxorubicin lead to premature ovarian insufficiency as an off-target
effect. However, their oocyte death pathway has been debated. Here, we clarified the …

STUDY QUESTION What are the effects of cyclophosphamide exposure on the human ovary
and can anti-Mullerian hormone (AMH) and rapamycin protect against these? SUMMARY …

Ovarian follicle pool depletion, infertility, and premature menopause are all known sequelae
of cancer treatment that negatively impact the quality of life of young cancer survivors. The …

Gonadotoxic chemotherapeutics, such as cyclophosphamide, can cause early menopause
and infertility in women. Earlier histological studies showed ovarian reserve depletion via …