Design of calcium phosphate ceramics for drug delivery applications in bone diseases: A review of the parameters affecting the loading and release of the therapeutic …

M Parent, H Baradari, E Champion, C Damia… - Journal of Controlled …, 2017 - Elsevier
Effective treatment of critical-size defects is a key challenge in restorative surgery of bone.
The strategy covers the implantation of biocompatible, osteoconductive, bioactive and …

Calcium phosphates as delivery systems for bisphosphonates

A Bigi, E Boanini - Journal of functional biomaterials, 2018 - mdpi.com
Bisphosphonates (BPs) are the most utilized drugs for the treatment of osteoporosis, and are
usefully employed also for other pathologies characterized by abnormally high bone …

Synthetic hydroxyapatite in pharmaceutical applications

J Kolmas, S Krukowski, A Laskus, M Jurkitewicz - Ceramics International, 2016 - Elsevier
Synthetic hydroxyapatite plays a key role in implantology, stomatology, and regenerative
medicine. Thanks to its non-toxicity and biocompatibility with bone and mineralised dental …

Efficient removal of heavy metal ions by diethylenetriaminepenta (methylene phosphonic) acid-doped hydroxyapatite

Z Zhao, X Zhang, D Ruan, H Xu, F Wang, W Lei… - Science of The Total …, 2022 - Elsevier
Diethylenetriaminepenta (methylene phosphonic) acid (DTPMP) was first used as a dopant
to modify hydroxyapatite and applied to remove Pb 2+. The adsorption capacity of modified …

The facile synthesis of zoledronate functionalized hydroxyapatite amorphous hybrid nanobiomaterial and its excellent removal performance on Pb2+ and Cu2+

X Fang, S Zhu, J Ma, F Wang, H Xu, M Xia - Journal of hazardous materials, 2020 - Elsevier
In this paper, a simple chemical precipitation method was proposed to obtain zoledronate
functionalized hydroxyapatite (zole-HAP) hybrid nano-biomaterials (zole-HAP-HNBM) which …

Adsorption performance of hydroxyapatite with different crystalline and porous structure towards metal ions in multicomponent solution

AI Ivanets, NV Kitikova, IL Shashkova… - Journal of Water …, 2019 - Elsevier
Hydroxyapatite (HA) is a well-known and widely used efficient adsorbent for toxic metal ion
and radionuclide removal from wastewater. However, the relationship between the structural …

Highly porous amorphous calcium phosphate for drug delivery and bio-medical applications

R Sun, M Åhlén, CW Tai, ÉG Bajnóczi, F de Kleijne… - Nanomaterials, 2019 - mdpi.com
Amorphous calcium phosphate (ACP) has shown significant effects on the biomineralization
and promising applications in bio-medicine. However, the limited stability and porosity of …

Alendronate release from calcium phosphate cement for bone regeneration in osteoporotic conditions

CIA van Houdt, PR Gabbai-Armelin, PM Lopez-Perez… - Scientific reports, 2018 - nature.com
Osteoporosis represents a major health problem in terms of compromising bone strength
and increasing the risk of bone fractures. It can be medically treated with bisphosphonates …

Targeted delivery as key for the success of small osteoinductive molecules

ER Balmayor - Advanced drug delivery reviews, 2015 - Elsevier
Molecules such as growth factors, peptides and small molecules can guide cellular behavior
and are thus important for tissue engineering. They are rapidly emerging as promising …

Molecular dynamics simulations of the binging affinity of 1-hydroxyethane-1, 1-diphosphonic acid (HEDP) with nano-hydroxyapatite and the uptake of Cu2+ by HEDP …

L Dong, S Zhu, M Xia, Y Chu, F Wang, W Lei - Journal of hazardous …, 2020 - Elsevier
The adsorption capacities of different ratios of 1-hydroxyethylidene-1, 1-diphosphonic acid
(HEDP) and nano-hydroxyapatite (HAP) hybrid systems on Cu 2+ were probed. The FTIR …