Immune regulation is fundamental to any immune response to ensure that it is appropriate
for the perceived threat to the host. Following cell and organ transplantation, it is essential to …

The explosion of new discoveries in the field of immunology has provided new insights into
mechanisms that promote an immune response directed against a transplanted organ …

Abstract CD4+ CD25+ regulatory T cells (Treg) have been shown to maintain immune
tolerance against self and foreign Ags, but their role in persistent viral infection has not been …

Substantial progress in understanding the biology of regulatory T cells and their roles in
health and disease has been achieved in the past 10 years. This has led to an increasing …

Abstract CD4+ CD25+ regulatory T (Treg) cells play a critical role in the induction and
maintenance of peripheral immune tolerance. In experimental transplantation models in …

T cell–depleting agents are being tested as part of clinical tolerance strategies in humans
with autoimmunity and transplantation. The immunosuppressive activity of anti-thymocyte …

Background. Although immunosuppression withdrawal in kidney recipients usually leads to
rejection, in some patients it does not, leading to a state of clinical operational tolerance …

Background. Immunosuppression in renal transplantation, although manageable in the short-
term, is a major hurdle for long-term graft survival. Recently, increased frequencies of CD4+ …

Operational tolerance (graft acceptance in an immunosuppression (IS)‐free environment)
after living‐donor liver transplantation (LDLT) could occur by our elective protocol in some …

Both mast cells (MCs) and regulatory T cells (Tregs) have gained attention as
immunosuppressive cell populations. To investigate a possible interaction, we used the Th1 …