Orofacial clefts (OFCs) rank as the second most common congenital birth defect in the
United States after Down syndrome and are the most common head and neck congenital …

Orofacial clefts are common birth defects and can occur as isolated, nonsyndromic events or
as part of Mendelian syndromes. There is substantial phenotypic diversity in individuals with …

Objective To assess the overall and cause specific mortality of people from birth to 55 years
with cleft lip and palate. Design Long term follow up study. Setting Danish register of deaths …

Orofacial clefts are the most common craniofacial birth defects and one of the most common
congenital malformations in humans. They require complex multidisciplinary treatment and …

The focus of this work is to highlight the most recent advances in the understanding of cleft
lip and palate occurrence. Information regarding research on long-term outcomes, genes …

BACKGROUND: Spontaneous mutations in germ cells increase with male age, but an
association between paternal age and congenital malformations is not well established. We …

Cleft lip with or without a cleft palate (CLP) and cleft palate alone (CPA) are common birth
defects, with a combined birth prevalence of about 1 to 2/1,000.(1) Affected children have a …

Cleft lip with or without cleft palate (CL/P) is the most commonly occurring craniofacial birth
defect. We provide insight into the genetic etiology of this birth defect by performing genome …

The authors conducted a nationwide study of the occurrence of cancer among 8,093 Danish
oral cleft cases born in 1936 through 1998 and followed in the Danish Cancer Registry from …

Background: Cancer and birth defects may share factors that influence risk. A malformation
may involve physiologic changes or changes in lifestyle that might affect cancer risks …