Survivors of childhood and adolescent cancer are one of the higher risk populations seen by
health care professionals. The curative therapy administered for the cancer also affects …

Since the introduction of multi-agent chemotherapy for osteosarcoma over 30 years ago,
overall survival has exceeded 50%. A clear understanding of the acute complications and …

The water channel aquaporin-2 (AQP2), expressed in the kidney collecting ducts, plays a
pivotal role in maintaining body water balance. The channel is regulated by the peptide …

Background Improvements in diagnostics and treatment for paediatric malignancies resulted
in a major increase in survival. However, childhood cancer survivors (CCS) are at risk of …

Purpose Relative efficacy and toxicity of cyclophosphamide compared with ifosfamide are
debatable. The Euro-EWING99-R1 trial asked whether cyclophosphamide may replace …

The presence of renal dysfunction in a patient receiving chemotherapy can be devastating.
Although many patients with cancer have underlying compromised renal function, some …

The aim of this multicentre study was to document the nephrotoxicity associated with
ifosfamide and evaluate risk factors in 148 children and young people with sarcomas who …

Results Survivors treated with nephrectomy and abdominal irradiation had significantly
lower estimated GFR than survivors not treated with nephrectomy/abdominal irradiation …

Improvements in childhood cancer therapy have led to increasing numbers of long‐term
survivors. These survivors are at risk for a variety of late effects due to the disease itself …

The use of anticancer drugs is beneficial for patients with malignancies but is frequently
associated with the occurrence of electrolyte disorders, which can be hazardous and in …