When fully extended, one copy of the three billion base pair human genome reaches a
length of over two meters. Yet, it must be packaged into the nucleus of a cell with an average …

Different types of human gene mutation may vary in size, from structural variants (SVs) to
single base‐pair substitutions, but what they all have in common is that their nature, size and …

Mutation rates along the genome are highly variable and influenced by several chromatin
features. Here, we addressed how nucleosomes, the most pervasive chromatin structure in …

We present a physics-based machine learning approach to predict in vitro transcription
factor binding affinities from structural and mechanical DNA properties directly derived from …

Pioneer transcription factors (TFs) function as genomic first responders, binding to
inaccessible regions of chromatin to promote enhancer formation. The mechanism by which …

There is increasing evidence for the presence of an alternative code imprinted in the
genome that might contribute to gene expression regulation through an indirect reading …

Ultraviolet (UV) light induces different classes of mutagenic photoproducts in DNA, namely
cyclobutane pyrimidine dimers (CPDs), 6-4 photoproducts (6-4PPs), and atypical thymine …

Methylation of DNA at CpG dinucleotides represents one of the most important epigenetic
mechanisms involved in the control of gene expression in vertebrate cells. In this report, we …

Nucleosomes are fundamental units of chromatin compaction, which organize∼ 200 DNA
base pairs using an octamer of histone proteins. Their ubiquitous presence in the cell …

Nucleosome positioning is an important process required for proper genome packing and its
accessibility to execute the genetic program in a cell-specific, timely manner. In the recent …