GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models

RJ Torphy, Y Sun, R Lin, A Caffrey-Carr… - Nature …, 2022 - nature.com
For many solid tumors, immune checkpoint blockade therapy has become first line
treatment, yet a large proportion of patients with immunologically cold tumors do not benefit …

Kicking sleepers out of bed: Macrophages promote reactivation of dormant Cryptococcus neoformans by extracellular vesicle release and non-lytic exocytosis

RJA de Castro, CL Marina, A Sturny-Leclère… - PLoS …, 2023 - journals.plos.org
Macrophages play a key role in disseminated cryptococcosis, a deadly fungal disease
caused by Cryptococcus neoformans. This opportunistic infection can arise following the …

The Role of Endothelial G Protein-Coupled Receptor 182 (GPR182) in the Tumor Microenvironment

RJ Torphy - 2021 - search.proquest.com
The abundance of lymphatic vessels in the tumor microenvironment has been reported to be
a negative prognostic marker across human malignancies as cancer cells can metastasize …

Investigating the role of Atypical Chemokine Receptor 3 in cancer development

A Karatza - 2020 - theses.gla.ac.uk
Atypical Chemokine Receptor 3 (ACKR3) is a seven-transmembrane spanning receptor with
pleiotropic functions in development, homeostasis and pathophysiology. The spatiotemporal …