Many human brain disorders are associated with characteristic alterations in the structural
and functional connectivity of the brain. In this article, we explore how commonalities and …

Post‐traumatic stress disorder (PTSD) and alcohol‐use disorder (AUD) are highly comorbid
in humans. Although we have some understanding of the structural and functional brain …

Synaptic loss and deficits in functional connectivity are hypothesized to contribute to
symptoms associated with major depressive disorder (MDD) and post-traumatic stress …

Intrinsic connectivity, measured using resting-state fMRI, has emerged as a fundamental tool
in the study of the human brain. However, due to practical limitations, many studies do not …

The amygdala processes valenced stimuli, influences emotion, and exhibits aberrant activity
across anxiety disorders, depression, and PTSD. Interventions modulating amygdala activity …

Background Connectivity between the amygdala and ventromedial prefrontal cortex
(vmPFC) is compromised in multiple psychiatric disorders, many of which emerge during …

Background High rates of comorbidity, shared risk, and overlapping therapeutic
mechanisms have led psychopathology research toward transdiagnostic dimensional …

Objective: The interpretability of results in psychiatric neuroimaging is significantly limited by
an overreliance on correlational relationships. Purely correlational studies cannot alone …

Objective: Anhedonia is central to multiple psychiatric disorders and causes substantial
disability. A dimensional conceptualization posits that anhedonia severity is related to a …

The amygdala is central to the pathophysiology of many psychiatric illnesses. An imprecise
understanding of how the amygdala fits into the larger network organization of the human …