Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …

The overlapping metabolic reprogramming of cancer and immune cells is a putative
determinant of the antitumor immune response in cancer. Increased evidence suggests that …

The employment of liquid chromatography‐mass spectrometry (LC‐MS) untargeted and
targeted metabolomics has led to the discovery of novel biomarkers and improved the …

Plasmodium falciparum causes the most lethal form of malaria. Peroxide antimalarials
based on artemisinin underpin the frontline treatments for malaria, but artemisinin resistance …

Vegans are at an increased risk for certain micronutrient deficiencies, foremost of vitamin
B12. Little is known about the short-term effects of dietary change to plant-based nutrition on …

Understanding mechanisms of epigenetic regulation in embryonic stem cells (ESCs) is of
fundamental importance for stem cell and developmental biology. Here, we identify Spic, a …

S-adenosylmethionine (SAM) is essential for methyl transfer reactions. All SAM is produced
de novo via the methionine cycle. The demethylation of SAM produces S …

Abstract Phenylketonuria (PKU, MIM# 261600) is one of the most common inborn errors of
metabolism (IEM) with an incidence of 1: 10000 in the European population. PKU is caused …

Glioblastoma (GBM), the most malignant tumor of the central nervous system, is marked by
its dynamic response to microenvironmental niches. In particular, this cellular plasticity …

The presence of acids and bases, coupled with its exceptional CO 2 adsorption capacity and
thermal stability, has established zirconia as a highly esteemed promoter and carrier …