The non-canonical Wnt/Ca2+ signaling cascade is less characterized than their canonical
counterpart, the Wnt/b-catenin pathway. The non-canonical Wnt signaling pathways are …

In addition to activating β-catenin/TCF transcriptional complexes, Wnt proteins can elicit a
variety of other responses. These are often lumped together under the denominator …

Wnt signaling plays a critical role in embryonic development, and genetic aberrations in this
network have been broadly implicated in colorectal cancer. We find that the Wnt receptor …

WNT ligands induce Ca2+ signalling on target cells. PKD1 (polycystin 1) is considered an
orphan, atypical G-protein-coupled receptor complexed with TRPP2 (polycystin 2 or PKD2) …

Receptor tyrosine kinases of the Ryk and Ror families were initially classified as orphan
receptors because their ligands were unknown. They are now known to contain functional …

The Wnt pathway is a major embryonic signaling pathway that controls cell proliferation, cell
fate, and body-axis determination in vertebrate embryos. Soon after egg fertilization, Wnt …

Gastrulation and neurulation are successive morphogenetic processes that play key roles in
shaping the basic embryonic body plan. Importantly, they operate through common cellular …

Wnt proteins control diverse biological processes through β-catenin-dependent canonical
signalling and β-catenin-independent non-canonical signalling. The mechanisms by which …

Wnt signaling pathways and microRNAs (miRNAs) are critical regulators of development.
Aberrant Wnt signaling pathways and miRNA levels lead to developmental defects and …

WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required
for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals …