Aging is a complex biological process characterized by hallmark features accumulating over
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …

NAFLD/NASH is a sex‐dimorphic disease, with a general higher prevalence in men. Women
are at reduced risk of NAFLD compared to men in fertile age, whereas after menopause …

Cellular senescence is induced by stresses and results in a stable proliferation arrest
accompanied by a pro-inflammatory secretome. Senescent cells accumulate during aging …

Nonalcoholic fatty liver disease (NAFLD) embraces the clinico-pathological consequences
of hepatic lipotoxicity and is a major public health problem globally. Sexual dimorphism is a …

Peroxisome proliferator-activated receptors (PPAR), ligand-activated transcription factors of
the nuclear hormone receptor superfamily, have been identified as key metabolic regulators …

Precision medicine defines the attempt to identify the most effective approaches for specific
subsets of patients based on their genetic background, clinical features, and environmental …

Biological sex is a fundamental source of phenotypic variability across species. Males and
females have different nutritional needs and exhibit differences in nutrient digestion and …

Preserving skeletal muscle function is essential to maintain life quality at high age. Calorie
restriction (CR) potently extends health and lifespan, but is largely unachievable in humans …

(1) Background: Excess weight in the form of adiposity plays a key role in the pathogenesis
of cardiometabolic diseases. Lifestyle modifications that incorporate continuous energy …

With the prevalence of obesity alarmingly increasing, it is of primary interest to identify those
factors predicting the success of anti-obesity therapeutic strategies currently adopted in …