We previously proposed a clinical state of metastasis termed'oligometastases' that refers to
restricted tumor metastatic capacity. The implication of this concept is that local cancer …

Metastasis is a multistage process that requires cancer cells to escape from the primary
tumour, survive in the circulation, seed at distant sites and grow. Each of these processes …

Background The stromal microenvironment and particularly the macrophage component of
primary tumors influence their malignant potential. However, at the metastatic site the role of …

Various types of tumors, particularly those originating from the ovary and gastrointestinal
tract, display a strong predilection for the peritoneal cavity as the site of metastasis. The …

Background This study aimed to provide information on timing, anatomical location, and
predictors for metachronous metastases of colorectal cancer based on a large consecutive …

Metastasis is the main cause of tumor-related death, and the dispersal of tumor cells through
the circulatory system is a critical step in the metastatic process. Early detection and analysis …

Eight million people die of cancer each year and 90% of deaths are caused by systemic
disease. Circulating tumor cells (CTCs) contribute to the formation of metastases and thus …

Background Experimental and observational research suggests that combined epidural–
general anesthesia may improve long-term survival after cancer surgery by reducing …

Chemotherapy is a double-edged sword. It is anticancer because of its cytotoxicity.
Paradoxically, by increasing chemoresistance and cancer metastasis, it is also procancer …

In 1889, Dr. Stephen Paget proposed the “seed and soil” hypothesis, which states that
cancer cells (the seeds) need the proper microenvironment (the soil) for them to grow …