Immune responses in the glaucomatous retina: regulation and dynamics
Glaucoma is a multifactorial disease resulting in progressive vision loss due to retinal
ganglion cell (RGC) dysfunction and death. Early events in the pathobiology of the disease …
ganglion cell (RGC) dysfunction and death. Early events in the pathobiology of the disease …
Gene therapy and transplantation in CNS repair: the visual system
AR Harvey, Y Hu, SG Leaver, CB Mellough… - Progress in retinal and …, 2006 - Elsevier
Normal visual function in humans is compromised by a range of inherited and acquired
degenerative conditions, many of which affect photoreceptors and/or retinal pigment …
degenerative conditions, many of which affect photoreceptors and/or retinal pigment …
The transcriptome of retinal Müller glial cells
K Roesch, AP Jadhav, JM Trimarchi… - Journal of …, 2008 - Wiley Online Library
ABSTRACT Müller glial cells are the major type of glia in the mammalian retina. To identify
the molecular machinery that defines Müller glial cell identity and function, single cell gene …
the molecular machinery that defines Müller glial cell identity and function, single cell gene …
Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line
Retinal ganglion cell (RGC) injury and cell death from glaucoma and other forms of optic
nerve disease is a major cause of irreversible vision loss and blindness. Human pluripotent …
nerve disease is a major cause of irreversible vision loss and blindness. Human pluripotent …
Epiretinal cell proliferation in macular pucker and vitreomacular traction syndrome: analysis of flat-mounted internal limiting membrane specimens
F Zhao, A Gandorfer, C Haritoglou, R Scheler… - Retina, 2013 - journals.lww.com
Purpose: To describe new details of epiretinal cell proliferation in flat-mounted internal
limiting membrane specimens. Methods: One hundred nineteen internal limiting membrane …
limiting membrane specimens. Methods: One hundred nineteen internal limiting membrane …
Inflammasome activation induces pyroptosis in the retina exposed to ocular hypertension injury
A Pronin, D Pham, W An, G Dvoriantchikova… - Frontiers in molecular …, 2019 - frontiersin.org
Mechanical stress and hypoxia during episodes of ocular hypertension (OHT) trigger glial
activation and neuroinflammation in the retina. Glial activation and release of pro …
activation and neuroinflammation in the retina. Glial activation and release of pro …
Inactivation of astroglial NF‐κB promotes survival of retinal neurons following ischemic injury
G Dvoriantchikova, D Barakat… - European Journal of …, 2009 - Wiley Online Library
Reactive astrocytes have been implicated in neuronal loss following ischemic stroke.
However, the molecular mechanisms associated with this process are yet to be fully …
However, the molecular mechanisms associated with this process are yet to be fully …
Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosis
HR Pelzel, CL Schlamp, RW Nickells - BMC neuroscience, 2010 - Springer
Background Silencing of normal gene expression occurs early in the apoptosis of neurons,
well before the cell is committed to the death pathway, and has been extensively …
well before the cell is committed to the death pathway, and has been extensively …
Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury
G Dvoriantchikova, D Ivanov, D Barakat, A Grinberg… - PloS one, 2012 - journals.plos.org
Pannexin1 (Panx1) forms large nonselective membrane channel that is implicated in
paracrine and inflammatory signaling. In vitro experiments suggested that Panx1 could play …
paracrine and inflammatory signaling. In vitro experiments suggested that Panx1 could play …
Enriched retinal ganglion cells derived from human embryonic stem cells
Optic neuropathies are characterised by a loss of retinal ganglion cells (RGCs) that lead to
vision impairment. Development of cell therapy requires a better understanding of the …
vision impairment. Development of cell therapy requires a better understanding of the …