Glaucoma is a multifactorial disease resulting in progressive vision loss due to retinal
ganglion cell (RGC) dysfunction and death. Early events in the pathobiology of the disease …

Normal visual function in humans is compromised by a range of inherited and acquired
degenerative conditions, many of which affect photoreceptors and/or retinal pigment …

ABSTRACT Müller glial cells are the major type of glia in the mammalian retina. To identify
the molecular machinery that defines Müller glial cell identity and function, single cell gene …

Retinal ganglion cell (RGC) injury and cell death from glaucoma and other forms of optic
nerve disease is a major cause of irreversible vision loss and blindness. Human pluripotent …

Purpose: To describe new details of epiretinal cell proliferation in flat-mounted internal
limiting membrane specimens. Methods: One hundred nineteen internal limiting membrane …

Mechanical stress and hypoxia during episodes of ocular hypertension (OHT) trigger glial
activation and neuroinflammation in the retina. Glial activation and release of pro …

Reactive astrocytes have been implicated in neuronal loss following ischemic stroke.
However, the molecular mechanisms associated with this process are yet to be fully …

Background Silencing of normal gene expression occurs early in the apoptosis of neurons,
well before the cell is committed to the death pathway, and has been extensively …

Pannexin1 (Panx1) forms large nonselective membrane channel that is implicated in
paracrine and inflammatory signaling. In vitro experiments suggested that Panx1 could play …

Optic neuropathies are characterised by a loss of retinal ganglion cells (RGCs) that lead to
vision impairment. Development of cell therapy requires a better understanding of the …