Alkaline phosphatase is an enzyme commonly expressed in almost all living organisms. In
humans and other mammals, determinations of the expression and activity of alkaline …

Human embryonic stem cells (hESCs) are pluripotent stem cells with long-lasting capacity to
self-renew and differentiate into various cell types of endodermal, ectodermal or …

Although the detection of several components of the fibroblast growth factor (FGF) signaling
pathway in human embryonic stem cells (hESCs) has been reported, the functionality of that …

Previously, we have shown that Wnt-5a strongly regulates dopaminergic neuron
differentiation by inducing phosphorylation of Dishevelled (Dvl). Here, we identify additional …

LDL-related protein 6 (LRP6) is a coreceptor of WNTs and a key regulator of the WNT/β-
catenin pathway. Upon activation, LRP6 is phosphorylated within its intracellular PPPS/TP …

Dishevelled (DVL) is a key scaffolding protein and a branching point in Wnt signaling
pathways. Here, we present conclusive evidence that DVL regulates the centrosomal cycle …

Mouse embryonic stem cells (mESCs) represent a unique tool for many researchers;
however, the process of ESC derivation is often very inefficient and requires high …

Embryonic stem cells combine the features of robust proliferation with precise differentiation
capacity. p27 is a cell cycle inhibitor that is involved in the regulation of proliferation and …

Dishevelled (DVL) is the key component of the Wnt signaling pathway. Currently, DVL
conformational dynamics under native conditions is unknown. To overcome this limitation …

Self-renewal and pluripotency of human embryonic stem cells (hESCs) are a complex
biological process for maintaining hESC stemness. However, the molecular mechanisms …