Periodontal inflammation and systemic diseases: an overview

M Martínez-García, E Hernández-Lemus - Frontiers in physiology, 2021 - frontiersin.org
Periodontitis is a common inflammatory disease of infectious origins that often evolves into a
chronic condition. Aside from its importance as a stomatologic ailment, chronic periodontitis …

[HTML][HTML] Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders

R Vlashi, X Zhang, M Wu, G Chen - Genes & Diseases, 2023 - Elsevier
Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

[HTML][HTML] Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity

DW Williams, T Greenwell-Wild, L Brenchley, N Dutzan… - Cell, 2021 - cell.com
The oral mucosa remains an understudied barrier tissue. This is a site of rich exposure to
antigens and commensals, and a tissue susceptible to one of the most prevalent human …

No genetic causal association between periodontitis and arthritis: A bidirectional two-sample mendelian randomization analysis

KJ Yin, JX Huang, P Wang, XK Yang, SS Tao… - Frontiers in …, 2022 - frontiersin.org
Objectives Periodontitis (PD) has been linked to arthritis in previous epidemiological
observational studies; however, the results are inconclusive. It remains unclear whether the …

Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into …

JS Ong, J An, X Han, MH Law, P Nandakumar… - Gut, 2022 - gut.bmj.com
Objective Gastro-oesophageal reflux disease (GERD) has heterogeneous aetiology
primarily attributable to its symptom-based definitions. GERD genome-wide association …

Current state and challenges of the global outcomes of dental caries research in the meta-omics era

DG Moussa, P Ahmad, TA Mansour… - Frontiers in Cellular and …, 2022 - frontiersin.org
Despite significant healthcare advances in the 21st century, the exact etiology of dental
caries remains unsolved. The past two decades have witnessed a tremendous growth in our …

Genetic evidence strengthens the bidirectional connection between gut microbiota and periodontitis: insights from a two-sample Mendelian randomization study

X Ye, B Liu, Y Bai, Y Cao, S Lin, L Lyu, H Meng… - Journal of Translational …, 2023 - Springer
Background Recent research has established the correlation between gut microbiota and
periodontitis via oral-gut axis. Intestinal dysbiosis may play a pivotal bridging role in extra …

Challenges and solutions in polymer drug delivery for bacterial biofilm treatment: a tissue-by-tissue account

K Kasza, P Gurnani, KR Hardie, M Camara… - Advanced drug delivery …, 2021 - Elsevier
To tackle the emerging antibiotic resistance crisis, novel antimicrobial approaches are
urgently needed. Bacterial communities (biofilms) are a particular concern in this context …

Association between circulating 25‐hydroxyvitamin D metabolites and periodontitis: Results from the NHANES 2009–2012 and Mendelian randomization study

W Li, Q Zheng, M Xu, C Zeng… - Journal of clinical …, 2023 - Wiley Online Library
Aim This study sought to investigate associations of 25‐hydroxyvitamin D (25 (OH) D)
metabolites with periodontitis and to assess causality using Mendelian randomization (MR) …

Causal effects of gut microbiota on the risk of periodontitis: a two-sample Mendelian randomization study

S Luo, W Li, Q Li, M Zhang, X Wang, S Wu… - Frontiers in Cellular and …, 2023 - frontiersin.org
Introduction The oral cavity and the gut tract are interconnected, and both contain abundant
natural microbiota. Gut microbiota may interact with oral flora and participate in the …