Bone tissue is the structural component of the body, which allows locomotion, protects vital
internal organs, and provides the maintenance of mineral homeostasis. Several bone …

Bone loss associated with fracture nonunion, revision total joint arthroplasty (TJA), and
pseudoarthrosis of the spine presents a challenging clinical scenario for the orthopaedic …

Bone is a dynamic environment where osteocytes, osteoblasts, and mesenchymal
stem/progenitor cells perceive mechanical cues and regulate bone metabolism accordingly …

Small animal models have demonstrated the efficacy of ex vivo regional gene therapy using
scaffolds loaded with BMP‐2‐expressing mesenchymal stem cells (MSCs). Prior to clinical …

Cellular plasticity refers to the ability of cell fates to be reprogrammed given the proper
signals, allowing for dedifferentiation or transdifferentiation into different cell fates. In vitro …

Novel biomaterials for stem cell engineering have been widely recognized in both scientific
research and clinical practice. These biomaterials mainly include local delivery materials …

Cílem této habilitační práce je představit pokrok v oblasti výzkumu experimentální
mechaniky biologických tkání, biomateriálů a náhrad, kterého bylo dosaženo na pracovišti …

目的: 探讨过表达叉头转录因子1 (FOXO1) 的骨髓间充质干细胞(BMSCs)
对哮喘小鼠肺嗜酸性粒细胞浸润和气道重构的抑制作用, 并阐明其可能的作用机制. 方法方法 …

This study demonstrates the effect of various processing conditions on the mechanical,
structural and utility characteristics of collagen materials to be used for bone tissue …