Hydroethidine (HE; or dihydroethidium) is the most popular fluorogenic probe used for
detecting intracellular superoxide radical anion. The reaction between superoxide and HE …

The intracellular signal transduction of AngII (angiotensin II) has been implicated in
cardiovascular diseases, such as hypertension, atherosclerosis and restenosis after injury …

We have shown previously that T cells are required for the full development of angiotensin II–
induced hypertension. However, the specific subsets of T cells that are important in this …

Endothelial cells exert an enormous influence on blood vessels throughout the circulation,
but their impact is particularly pronounced in the brain. New concepts have emerged …

Angiotensin II (Ang II) produces inflammation and endothelial dysfunction in blood vessels.
We tested the hypothesis that interleukin 10 (IL-10), an antiinflammatory cytokine, protects …

Objective—The goal of this study was to test the hypothesis that IL-6 mediates the increases
in superoxide, vascular hypertrophy, and endothelial dysfunction in response to angiotensin …

Atherosclerosis and associated ischemic organ dysfunction represent the number one
cause of mortality worldwide. While the key drivers of atherosclerosis, arterial hypertension …

Dementia is growing at an alarming rate worldwide. Although Alzheimer disease is the
leading cause, over 50% of individuals diagnosed with Alzheimer disease have vascular …

The small GTPase Rho and its downstream effector Rho-kinase contribute to agonist-
induced vascular contraction via Ca 2+ sensitization. Reasonably selective pharmacological …

β-Arrestins were initially shown, in conjunction with G protein-coupled receptor kinases, to
be involved in the desensitization and internalization of activated seven-transmembrane …