The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …

The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …

Increased tolerance of Plasmodium falciparum to front-line artemisinin antimalarials (ARTs)
is associated with mutations in Kelch13 (K13), although the precise role of K13 remains …

The use of artemisinin-based combination therapies (ACTs), which combine an artemisinin
derivative with a partner drug, in the treatment of uncomplicated malaria has largely been …

Malaria is one of our planet's most widespread and deadliest diseases, and there is an ever-
consistent need for new and improved pharmaceuticals. Natural products have been an …

Mutations in the Plasmodium falciparum Kelch 13 (PfK13) protein are associated with
artemisinin resistance. PfK13 is essential for asexual erythrocytic development, but its …

Plasmodium falciparum causes the most lethal form of malaria. Peroxide antimalarials
based on artemisinin underpin the frontline treatments for malaria, but artemisinin resistance …

The emergence and spread in Southeast Asia of Plasmodium falciparum resistance to
artemisinin (ART) derivatives, the cornerstone of first-line artemisinin-based combination …

With artemisinin-resistant Plasmodium falciparum parasites emerging in Africa, the need for
new antimalarial chemotypes is persistently high. The ideal pharmacodynamic parameters …

Although malaria remains a big burden to many countries that it threatens their socio-
economic stability, particularly in the countries where malaria is endemic, there have been …