Frailty in older adults

DH Kim, K Rockwood - New England Journal of Medicine, 2024 - Mass Medical Soc
Key Points Frailty in Older Adults Assessing frailty enables clinicians to predict the outcomes
and risks of health conditions, target the delivery of evidence-based interventions, and tailor …

Prevalence of frailty in 62 countries across the world: a systematic review and meta-analysis of population-level studies

R O'Caoimh, D Sezgin, MR O'Donovan… - Age and …, 2021 - academic.oup.com
Introduction The prevalence of frailty at population level is unclear. We examined this in
population-based studies, investigating sources of heterogeneity. Methods PubMed …

The degree of frailty as a translational measure of health in aging

SE Howlett, AD Rutenberg, K Rockwood - Nature Aging, 2021 - nature.com
Frailty is a multiply determined, age-related state of increased risk for adverse health
outcomes. We review how the degree of frailty conditions the development of late-life …

Multisystem physiological perspective of human frailty and its modulation by physical activity

JA Taylor, PL Greenhaff, DB Bartlett… - Physiological …, 2023 - journals.physiology.org
“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants

P Hanlon, BI Nicholl, BD Jani, D Lee… - The Lancet Public …, 2018 - thelancet.com
Background Frailty is associated with older age and multimorbidity (two or more long-term
conditions); however, little is known about its prevalence or effects on mortality in younger …

The continuum of aging and age-related diseases: common mechanisms but different rates

C Franceschi, P Garagnani, C Morsiani, M Conte… - Frontiers in …, 2018 - frontiersin.org
Geroscience, the new interdisciplinary field that aims to understand the relationship between
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …

ESPEN guidelines on definitions and terminology of clinical nutrition

T Cederholm, R Barazzoni, P Austin, P Ballmer, G Biolo… - Clinical nutrition, 2017 - Elsevier
Background A lack of agreement on definitions and terminology used for nutrition-related
concepts and procedures limits the development of clinical nutrition practice and research …

[HTML][HTML] Inflammation and frailty in the elderly: a systematic review and meta-analysis

P Soysal, B Stubbs, P Lucato, C Luchini, M Solmi… - Ageing research …, 2016 - Elsevier
The pathogenesis of frailty and the role of inflammation is poorly understood. We examined
the evidence considering the relationship between inflammation and frailty through a …

Frailty measurement in research and clinical practice: a review

E Dent, P Kowal, EO Hoogendijk - European journal of internal medicine, 2016 - Elsevier
One of the leading causes of morbidity and premature mortality in older people is frailty.
Frailty occurs when multiple physiological systems decline, to the extent that an individual's …

Prevalence of frailty and prefrailty among community-dwelling older adults in low-income and middle-income countries: a systematic review and meta-analysis

DD Siriwardhana, S Hardoon, G Rait… - BMJ open, 2018 - bmjopen.bmj.com
Objective To systematically review the research conducted on prevalence of frailty and
prefrailty among community-dwelling older adults in low-income and middle-income …