Boveri and beyond: Chromothripsis and genomic instability from mitotic errors
Mitotic cell division is tightly monitored by checkpoints that safeguard the genome from
instability. Failures in accurate chromosome segregation during mitosis can cause …
instability. Failures in accurate chromosome segregation during mitosis can cause …
[HTML][HTML] The regulatory role of mitotic catastrophe in hepatocellular carcinoma drug resistance mechanisms and its therapeutic potential
J Li, X Cheng, D Huang, R Cui - Biomedicine & Pharmacotherapy, 2024 - Elsevier
This review focuses on the role and underlying mechanisms of mitotic catastrophe (MC) in
the regulation of drug resistance in hepatocellular carcinoma (HCC). HCC is one of the …
the regulation of drug resistance in hepatocellular carcinoma (HCC). HCC is one of the …
Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair
Oncogene amplification on extrachromosomal DNA (ecDNA) is a pervasive driver event in
cancer, yet our understanding of how ecDNA forms is limited. In this study, we couple a …
cancer, yet our understanding of how ecDNA forms is limited. In this study, we couple a …
Repair and misrepair of telomeric DNA in dynamic interactions with PML nuclear bodies and lamin B1. A gear-wheel nuclear traffic.
Telomeres in epithelial tumours are usually maintained by telomerase, however, in the
breast cancer MDA-MB-231 cell line, polyploid cells, induced by doxorubicin (DOX) were …
breast cancer MDA-MB-231 cell line, polyploid cells, induced by doxorubicin (DOX) were …
The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance
Chromothripsis describes the catastrophic shattering of mis-segregated chromosomes
trapped within micronuclei. Although micronuclei accumulate DNA double-strand breaks …
trapped within micronuclei. Although micronuclei accumulate DNA double-strand breaks …